Abstract: Objective The drug treatment of Alzheimer's Disease(AD) was studied by summarizing the pathogenesis of AD, in order to provide reference and ideas for clinical rational drug use and the development of AD innovative drugs. Methods The related references in recent years both at home and abroad about the latest achievements of AD and the drug treatment were analyzed, collated and summarized. Results The causes of AD were complex, so there were many hypothesis of the pathogenesis about AD, now many of AD drugs are developed for single mechanism that can't consider of the different factors in Alzheimer' Disease and many of them have side effects, so this brings difficulties for clinical rational drug use. Conclusion The scholars have paid more attention to traditional Chinese medicine(TCM), because its unique treatment to AD. But it usually focused on the single composition, the compound of TCM、the multi-component studies have little advancements, so we must do more researches in this respect, in order to provide references and research ideas for innovative drugs.

Key words: Alzheimer' Disease, pathogenic mechanisms, drug treatment