Analysis of 73 Adverse Drug Reaction/Event Reports on Liver Damage Induced by Anticancer Drugs

Abstract

Abstract: Objective To investigate the epidemiological characteristics of liver damage induced by anticancer drugs. Methods With retrospective case study, analyzed 73 liver damage ADR/ADE reports induced by anticancer drugs in Jiangsu province from 2004 to June 2010. Results 73 ADR/ADE reports included 44 anticancer drugs, and the incidences of liver damage by Cisplatin、Gemcitabine and Vidarabine occupied the front 3 places in sequence. The drugs for intravenous administration resulted in the highest rate(86.3%), and most of the patients have ADR/ADE in 1~2 weeks. The clinical manifestations were jaundice, fatigue, fever, abdominal distension, abdominal pain, dark urine, nausea, edema, chest tightness, rash, itching, anorexia. Liver function examination showed that alanine amino transferase was in 48~2 610 U/L, and total bilirubin was in 6.7~260.1μmol/L in average. Conclusion It should be strengthening the observation and evaluation of liver damage induced by anticancer drugs.

Key words: anticancer drugs, liver damage, adverse drug reaction/event(ADR/ADE), gemcitabine

CLC Number:

R979.1

GAN Ge, GU Cheng-jie. Analysis of 73 Adverse Drug Reaction/Event Reports on Liver Damage Induced by Anticancer Drugs[J]. Chinese Journal of Pharmacovigilance, 2011, 8(11): 690-693.

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