Abstract: Objective To investigate the mechanism and the prognosis after water-sodium retention adverse reactions of infant induced by Licorzinc. Methods Combination of literature review and retrospective analysis 8 infant cases in our hospital induced water-sodium retention adverse reactions by Licorzinc. Results and conclusion Licorzinc induced infant water-sodium retention adverse reactions is due to direct or indirect aldosterone sample function, after withdrawal symptoms may itself disappear, Licorzinc not as infant the first-line use zinc patching.

Key words: Licorzinc, infant, water-sodium retention, adverse reaction