Research Development on Chemincal Compositions in Evodiamine Related with Efficacy and Toxicity

Abstract

Abstract: Objective By combing pertinent literature,and summarizing the current states of chemical composition of evodiamine related with its efficacy and toxicity, to identify its effective and toxical composition, offer the accordance and research ideas for further research on the relationship between efficacy, toxicity and chemical composition of evo-diamine. Methods The related references in recent 10 years both at home and abroad about evodiamine were analyzed, collated and summarized. Results Alkaloids are the main chemical constituents and active ingredients, and are the main material basis for efficacy in evodiamine; evodiamine has small toxicity documented in pharmacopoeia and lit-erature, but the research reports related to the toxicity of chemical constituents are very few and the research about toxicology of evodiamine is still not deep enough. Conclusion There is or not other effective chemical composition in evodiamine, and what is the toxical chemical composition in evodiamine, and the relevance between effective chemical composition and toxical chemical composition, and the "dose-efficacy" and "dose-toxicity"relationship between efficacy, toxicity and chemical composition in evodiamine, and so on; they are to be further deep study and to provide experimental evidence for the optimization、security and quality control、safety and rational use in clinic.

Key words: evodiamine, chemical composition, efficacy, toxicity

CLC Number:

R282

HUANG Wei, SUN Rong, BAO Zhi-ye, WANG Hui. Research Development on Chemincal Compositions in Evodiamine Related with Efficacy and Toxicity[J]. Chinese Journal of Pharmacovigilance, 2010, 7(8): 482-485.

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