Abstract: Objective To investigate the neuroprotective and mechanism of total flavones of bidens bipinnata L.(TFB) on brain damage following experimental intracerebral hemorrhage in rats. Methods Experimental intracerebral hemorrhage was induced in rats through infusion 50μL of fresh autologous blood drawn into the caudate uncleus. The brain water content, whole blood viscosity and the level of SOD, MDA and NO were measured. Results TFB (100mg·kg^-1、30mg·kg^-1、10mg·kg^-1) significant improve the brain water content and status whole blood viscosity. The level of MDA, NO was lower, and the level of SOD was obviously higher in high-, middle-dose TFB group in cerebral tissue( P<0.05). Conclusion TFB has evident protective effect on brain damage after experimental intracerebral hemorrhage in rats, which maybe related to diminished cerebral edema, improve the microcirculation status of peri-hematomal penumbra, the increased the ability of decreased lipid peroxidation, inhibited production of NO.

Key words: Key word: Total Flavones of Bidens bipinnata L. (TFB), experimental intracerebral hemorrhage, oxygen -derived free radicals, cerebral edema, whole blood viscosity