Abstract: Objective To mine and analyze data on adverse events among liver or kidney transplant recipients following COVID-19 vaccination based on the Vaccine Adverse Event Reporting System (VAERS). Methods The data on adverse events related to COVID-19 vaccines among liver or kidney transplant patients and collected between December 18, 2020 and May 24, 2023 was retrieved before being analyzed using disproportionality methods. Adverse events involving more than 3 cases were screened and analyzed via system organ classification. Results 253 and 817 adverse events related to COVID-19 vaccines were respectively collected among recipients of liver and kidney transplant. The common adverse reactions were headache, fatigue, fever, chills, limb pain, dizziness, cough and diarrhea, involving 13 system organ classifications of both liver and kidney transplant recipients. New adverse event signals that deserved clinical attention included deterioration of conditions, acute renal injury, elevated serum creatinine, atrial fibrillation, elevated alanine aminotransferase, transplant rejection, and decrease of blood oxygen saturation. Conclusion A number of new adverse event signals have been detected, which can provide reference for subsequent development of COVID-19 vaccines for liver and kidney transplant patients.

Key words: COVID-19, vaccine, liver transplant patient, recipients of kidney transplant, Vaccine Adverse Event Reporting System(VAERS), adverse event, system organ