Abstract: Objective To explore the adverse reactions to addiction caused by dezocine injection in an HIV patient and analyze the influencing factors so as to provide reference for clinical safety. Methods The clinical data of an HIV patient with dezocine injection addiction treated in our hospital was analyzed while the mechanism and influencing factors of dezocine injection addiction were discussed based on literature review. Results The mechanism of addiction to dezocine injection was related to partial activation of μ receptors, inhibition of serotonin reabsorption and norepinephrine reuptake, and κ receptor activation. This patient had been using dizocine injection for more than forty consecutive days. Too long a course of treatment and too high a dose could significantly increase the risk of addiction to dezocine. Conclusion In clinical application of dezocine injection, the indications should be strictly controlled to prevent abuse and avoid long-term use.

Key words: dezocine, drug dependence, analgesic therapy, HIV, addiction