Interactions of Psoralea corylifolia L. with Astragali Radix and Paeoniae Radix Rubra in rats based on pharmacokinetics

doi:10.19803/j.1672-8629.20211083

Abstract

Abstract: Objective To study the changes of plasma pharmacokinetic parameters of psoralen and isopsoralen, the main toxic components of psoralen, after the compatibility of Astragali Radix, Paeoniae Radix Rubra and Psoralea corylifolia L.. Methods Thirty-two male SD rats were randomly divided into four groups: Psoralea corylifolia L. group, Psoralea corylifolia L.-Astragali Radix group, Psoralea corylifolia L.- Paeoniae Radix Rubra group, Psoralea corylifolia L.-Astragali Radix- Paeoniae Radix Rubra group. Blood was collected from the inner canthus at 0.25, 0.5, 0.75, 1, 2, 4, 6, 8, 10, 12, and 24 h after single intragastric administration. Plasma concentrations of psoralen and isopsoralen were detected with the UPLC -MS/MS method, and pharmacokinetic parameters were calculated via a non-attoventricular model using DAS3.0 software. Results The c_max and AUC of psoralen and isopsoralen decreased significantly when Psoralea corylifolia L. was combined with Paeoniae Radix Rubra, so did the c_max of isopsoralen in rat plasma when Psoralea corylifolia L. was combined with Astragali Radix. However, after the combination of Psoralea corylifolia L. and Astragali Radix and Paeoniae Radix Rubra, the AUC_0-_t of psoralen and isopsoralen decreased significantly in rat plasma, so did the AUC_0-∞ and c_max of isopsoralen. Conclusion The combination of Astragali Radix, Paeoniae Radix Rubra and Psoralea Corylifolia L. can reduce the exposure of psoralen and isopsoralen in vivo. Paeoniae Radix Rubra or Astragali Radix plus Psoralea corylifolia L. can reduce plasma c_max and AUC_0-_t, but the MRT of isopsoralen in plasma of rats in the Psoralea corylifolia L.- Astragali Radix- Paeoniae Radix Rubra group is prolonged, the specific mechanism of which needs to be further studied.

Key words: Psoralea corylifolia L., Astragali Radix, Paeoniae Radix Rubra, compatibility, psoralen, isopsoralen, pharmacokinetics, rats

CLC Number:

R999.1
R961

ZHAI Yuxia, ZHANG Xiaoying, MEN Weijie, CHENG Liyuan, ZHANG Yue, ZHOU Kun. Interactions of Psoralea corylifolia L. with Astragali Radix and Paeoniae Radix Rubra in rats based on pharmacokinetics[J]. Chinese Journal of Pharmacovigilance, 2023, 20(2): 152-156.

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