Abstract: Objective To analyze the complex network of combined medications of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection in the treatment of coronary heart disease complicated with hypertension in the real world so as to provide reference for the selection of clinically effective regimens. Methods From the large-scale electronic medical electronic data warehouse constructed by the Institute of Clinical Basic Medicine of Chinese Academy of Chinese Medical Sciences, the data of 1 930 patients with coronary heart disease and hypertension who had been treated with Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection between October 1, 2006 and December 30, 2015 was retrieved and analyzed based on the hospital information system(HIS). The Tabu search algorithm and complex network analysis method were used to conduct group module analysis. Results The average age of the 1 930 patients was (74.16±10.10) years old. Males patients outnumbered female ones. Most of them were manual laborers. Most of the inpatients were in mild condition. Other comorbidities were mostly type 2 diabetes and cerebral infarction. The route of administration was intravenous drips. The drugs were used in line with the instructions. The average single dose was (12.85±4.46) mL. The average duration of administration was (4.36±2.16) days. Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection were preferably combined with isosorbide mononitrate + nicardipine/valsartan and amlodipine tablets, metoprolol/heparins/acetylsalicylic acid, atorvastatin/levcarne Ting and other programs in the treatment of coronary heart disease complicated with hypertension. For traditional Chinese medicine, Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection were combined with Safflower Injection + compound Danshen dropping pills + Shexiang Baoxin pills/Suxiao Jiuxin pills, Tongxin luo capsules, compound Ganmaoling granules/VC Yinqiao tablets/Yinhuang Buccal tablets/compound Huangliansu tablets, the Simo decoction oral liquid/qi and yin nourishing agent. Conclusion By dividing the core combined drugs used by the clinically cured and improving populations into sub-structures, we can see more clearly the relationships between the sub-groups of the core combined medications with western and traditional Chinese medicine and between the sub-structures of each sub-group, which provide clues to the selection of clinically superior programs and pathways.

Key words: Ligustrazine hydrochloride, injection, real-world study, coronary heart disease, hypertension, combined medication