Literature Analysis of Anaphylactic Shock Induced by Reduced Glutathione for Injection

doi:10.19803/j.1672-8629.2021.07.16

Abstract

Abstract: Objective To explore the clinical characteristics and regularity of anaphylactic shock by caused by reduced glutathione for injection in order to provide data for clinical rational drug use. Methods Related literature published between January 1979 and September 2019 was retrieved from CNKI, Wanfang databases, VIP and Pubmed. The age, gender, daily dose, time for medication of anaphylactic shock, combined medication, preexisting diseases, clinical manifestations as well as prognosis were analyzed. Results A total of 27 case reports related to anaphylactic shock and involving 30 patients were collected. Patients with immediate anaphylactic shock (within 30 minutes of medication ) accounted for 93.9% of the total. The initial symptoms of anaphylactic shock mainly involved the respiratory system (chest tightness, dyspnea and asthma) and the circulatory system (sudden drop of blood pressure, cyanosis of the mouth and lips). Conclusion Anaphylactic shock caused by reduced glutathione for injection in severe cases can lead to fatal events, especially within 30 minutes. The symptoms of patients should be closely monitored to prevent fatal events.

Key words: reduced glutathione, anaphylactic shock, rational use of drugs

CLC Number:

R994.11

XI Yuling, HUI Hongyan, GUO Xiaohe, DENG Zhijian. Literature Analysis of Anaphylactic Shock Induced by Reduced Glutathione for Injection[J]. Chinese Journal of Pharmacovigilance, 2021, 18(7): 674-677.

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