Abstract: Objective To explore the treatments of acute coagulation dysfunction by cefoperazone sulbactam sodium. Methods A case who diagnosed with acute coagulation dysfunction due to cefoperazone sulbactam sodium was analyzed, we were trying to explore the treatments by medical literature retrieval. Results The patient was diagnosed as dysfunction of blood coagulation due to cefoperazone sulbactam sodium and the drug was stopped the same day, change with IV infusion of piperacillin tazobactam sodium and intramuscular injection of vitamin K1. The coagulation index of the patient decreased gradually and returned to normal on the 4th day after drug withdrawal. Conclusion Acute coagulation dysfunction caused by cefoperazone sulbactam sodium should stop infusing immediately, and intramuscular injection of vitamin K1 must be given with infusion of fresh frozen plasma.

Key words: cefoperazone sulbactam sodium, adverse reaction, coagulation disorders, vitamin K1