中国药物警戒 ›› 2012, Vol. 9 ›› Issue (3): 170-172.

• 综述 • 上一篇    下一篇

基于功效和物质基础的细辛毒性研究进展

栾永福1，2，李晓骄阳3，孙蓉1，*   

  1. 1 山东省中医药研究院，山东 济南 250014；
    2 天津中医药大学，天津 300193；
    3 中国药科大学药学院，江苏 南京 210009
  • 收稿日期:2011-10-31 出版日期:2012-03-10 发布日期:2015-08-10
  • 通讯作者: 孙蓉,女,研究员,硕士生导师,中药药理与毒理研究。E-mail：sunrong107@163.com
  • 作者简介:栾永福，男，硕士研究生，中药药理与毒理研究。
  • 基金资助:
    国家重点基础研究发展计划 （973）中医基础理论专项资助项目 （2009CB522802）

Research Development on Toxicity of Asarum Related to Efficacy and Chemical Material Basis

LUAN Yong-fu1, 2, LI Xiao-jiao-yang3, SUN Rong1   

  1. 1 Shandong Research Academy of TCM, Shandong Jinan 250014, China;
    2 Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;
    3 School of Pharmaceutical Sciences, China Pharmaceutical University, Jiangsu Nanjing 210009, China
  • Received:2011-10-31 Online:2012-03-10 Published:2015-08-10

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摘要： 目的为进行功效和毒性导向下的化学成分分离、控制和功效与毒性成分的“量效关系”和“量毒关系”研究提供文献依据和研究思路。方法对文献古籍中对细辛毒性的记载及近十几年来国内外相关文献对细辛的报道进行整理、分析与归纳。结论只有在细辛功效表达和功效物质基础分离与控制的过程中，进行毒性的研究和毒性物质基础的安全控制，才能提出切合细辛临床使用过程中预防药品不良反应的预警方案和早期诊疗措施，确保细辛临床用药安全。

关键词: 细辛, 功效, 物质基础, 毒性

Abstract: Objective To provide literature evidences asis and research ideas of efficacy and toxicity of the chemical composition of guided separation,control and efficacy, and the research on the "dose-effect relationship" and "dose-toxicity relationship” about the toxicial components. MethodsReferences in old days and in the last decades both at home and abroad about Asarum were collated,analyzed and summarized. ConclusionThe research on Asarum about the toxicity and margin of safety control based on the chemical separation and quality control about the effective material basis combined with the process of the effectiveness of expression,so as to provide consummating safety standards and putting forward early-warning scheme of adverse reaction,the early diagnosis and treatment measures that can be referred to clinical usage. Asarum will be ensured to use safety as a clinical drug.

Key words: Asarum, efficacy, material basis, toxicity