中国药物警戒 ›› 2025, Vol. 22 ›› Issue (4): 436-441.
DOI: 10.19803/j.1672-8629.20240557

• 安全与合理用药 • 上一篇    下一篇

骨伤科中成药用药警戒

杨静琦1, 许保海1, 张静1, 姜洋2, 侍方2   

  1. 1首都医科大学附属北京积水潭医院中药房,北京 100035;
    2首都医科大学附属北京积水潭医院中医科,北京 100035
  • 收稿日期:2024-08-12 发布日期:2025-04-17
  • 作者简介:杨静琦,女,硕士,主管药师,临床药学。
  • 基金资助:
    2019年全国中药特色技术传承人才培训项目（T20194828003）; 北京市医院管理中心科研培育项目（PZ2017011）

Pharmacovigilance for Traditional Chinese Patent Medicines for Orthopedics

YANG Jingqi1, XU Baohai1, ZHANG Jing1, JIANG Yang2, SHI Fang2   

  1. 1Pharmacy of Traditional Chinese Medicine, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China;
    2Department of TCM, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China
  • Received:2024-08-12 Published:2025-04-17

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摘要： 目的 对2024年北京积水潭医院3个院区的骨伤科中成药临床用药情况进行梳理,总结分析用药警戒相关信息,保障临床用药合理安全。方法 通过药品不良反应（ADR）监测数据报告、医院信息管理系统和药品说明书对药品相关数据进行整理分析,统计骨伤科中成药所导致的ADR案例、用药禁忌信息及含毒性成分情况。结果 骨伤科中成药ADR多发于女性、中老年人群,累及系统-器官以皮肤、神经、消化系统为主;药品禁忌信息主要涉及特殊人群、疾病证候、饮食、联合用药等;含毒性成分骨伤科中成药占45.31%,含乌头类毒性成分最多。结论 骨伤科中成药在临床治疗中占比较大,药品禁忌内容涉及广泛,且骨伤用药多含毒性成分,临床应提高药物警戒意识。

关键词: 骨伤科, 中成药, 乌头碱, 药品不良反应, 特殊人群, 毒性成分, 用药警戒

Abstract: Objective To trace medications with traditional Chinese patent medicines used in orthopedics departments in three locations of Beijing Jishuitan Hospital in 2024 and analyze the information related to pharmacovigilance so as to ensure rational and safe medications. Methods Data on usage of drugs was analyzed based on reports on adverse drug reactions, the hospital information management system and drug instructions. Cases of ADR caused by traditional Chinese patent medicines for orthopedics, data on drug contraindications, and toxic ingredients were statistically analyzed. Results ADR due to Traditional Chinese patent medicines in the orthopedics department were more prevalent in females or middle-aged and elderly people. The systems-organs involved were mostly the skin, nerves and the digestive system. Information about drug contraindications involved special populations, disease syndromes, diet and combined medications. Traditional Chinese patent medicines containing toxic components used by the orthopedics department accounted for 45.31% of the total, with aconitum as the dominating toxic component. Conclusion Traditional Chinese patent medicines are frequently used in orthopedics. There is a wide range of contraindications, and most of the drugs for orthopedics contain toxic ingredients, so pharmacovigilance is required.

Key words: Orthopedics, Traditional Chinese Patent Medicines, Aconitum, Adverse Drug Reaction, Special Populations, Toxic Components, Pharmacovigilance

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