中国药物警戒 ›› 2025, Vol. 22 ›› Issue (5): 586-588.
DOI: 10.19803/j.1672-8629.20240775

• 安全与合理用药 • 上一篇    下一篇

华法林钠片与迈之灵片联用致国际标准化比值异常升高1例分析

刘维婷, 魏巍, 杨彦彪*   

  1. 兰州市第一人民医院药剂科,甘肃 兰州 730050
  • 收稿日期:2024-10-08 出版日期:2025-05-15 发布日期:2025-05-19
  • 通讯作者: *杨彦彪,男,本科,主任药师,医院药学管理与药物警戒。E-mail:lzsdyyy_yyb@163.com
  • 作者简介:刘维婷,女,硕士,主管药师,抗凝临床药学。
  • 基金资助:
    甘肃省科技计划项目(23JRRA1789)

One Case of Abnormal Elevation of International Normalized Ratio Caused by Simultaneous Application of Sodium Warfarin Tablets and Aescuven Forte Tablets

LIU Weiting, WEI Wei, YANG Yanbiao*   

  1. Department of Pharmacy, the First pepole's Hospital of Lanzhou, Lanzhou Gansu 730050, China
  • Received:2024-10-08 Online:2025-05-15 Published:2025-05-19

摘要: 目的 探讨华法林钠片与迈之灵片联用致患者国际标准化比值(INR)异常升高的不良反应,为临床安全用药提供参考。方法 对1 例瓣膜置换后长期口服华法林钠片的患者,在联用迈之灵片后出现反复性鼻腔、牙龈出血及INR异常升高进行分析及文献回顾,并分析其原因与防治措施。结果 结合患者临床表现与给药时间的相关性,华法林钠片与迈之灵片联用致INR异常升高为很可能。经停用2种药后,患者INR逐渐恢复正常。结论 迈之灵片与华法林钠片联用可能会导致INR异常升高,引发出血等不良反应。临床在联用2种药物时,需特别注意不良反应的发生风险,密切监测患者凝血指标并关注出血情况。

关键词: 华法林, 迈之灵, 国际标准化比值, 药品不良反应, 药物相互作用

Abstract: Objective To explore such adverse reactions as an abnormal increase in the international normalized ratio caused by the combination of warfarin sodium tablets and Aescuven forte tablets in order to provide a reference for safe clinical use. Methods Related literature was reviewed for a patient who had been taking warfarin sodium tablets for an extended period of time following a valve replacement. Upon the addition of Aescuven forte tablets to his medication regimen, the patient experienced recurrent episodes of nasal and gum bleeding, as well as an abnormally elevated international normalized ratio. The potential causes and preventative measures were explored. Results Based on the correlation between the patient’s clinical manifestations and the time of administration, it was suspected that the adverse reaction was caused by the interactions between warfarin sodium tablets and Aescuven forte tablets. After the two drugs were discontinued, the patient’s indicators gradually returned to normal. Conclusion The concurrent use of Aescuven forte tablets and warfarin sodium tablets may result in abnormal elevations of the international normalized ratio, potentially leading to such adverse reactions as bleeding. When these two drugs are used in combination in clinic, it is crucial to closely monitor the patient’s coagulation indicators and be alert to signs of bleeding.

Key words: Warfarin, Aescuven Forte, International Normalized Ratio, Adverse Drug Reaction, Drug Interaction

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