关键词: 华法林, 迈之灵, 国际标准化比值, 药品不良反应, 药物相互作用

Abstract: Objective To explore such adverse reactions as an abnormal increase in the international normalized ratio caused by the combination of warfarin sodium tablets and Aescuven forte tablets in order to provide a reference for safe clinical use. Methods Related literature was reviewed for a patient who had been taking warfarin sodium tablets for an extended period of time following a valve replacement. Upon the addition of Aescuven forte tablets to his medication regimen, the patient experienced recurrent episodes of nasal and gum bleeding, as well as an abnormally elevated international normalized ratio. The potential causes and preventative measures were explored. Results Based on the correlation between the patient’s clinical manifestations and the time of administration, it was suspected that the adverse reaction was caused by the interactions between warfarin sodium tablets and Aescuven forte tablets. After the two drugs were discontinued, the patient’s indicators gradually returned to normal. Conclusion The concurrent use of Aescuven forte tablets and warfarin sodium tablets may result in abnormal elevations of the international normalized ratio, potentially leading to such adverse reactions as bleeding. When these two drugs are used in combination in clinic, it is crucial to closely monitor the patient’s coagulation indicators and be alert to signs of bleeding.

Key words: Warfarin, Aescuven Forte, International Normalized Ratio, Adverse Drug Reaction, Drug Interaction