中国药物警戒 ›› 2025, Vol. 22 ›› Issue (5): 583-585.
DOI: 10.19803/j.1672-8629.20240804

• 安全与合理用药 • 上一篇    下一篇

西吡氯铵含漱液致味觉障碍1例分析

钱霞1, 郑利光1,*, 李彤彤2, 贺亚春3   

  1. 1北京大学口腔医院药剂科,国家口腔医学中心,国家口腔疾病临床医学研究中心,口腔数字化医疗技术和材料国家工程实验室,北京 100081;
    2北京大学口腔医学院口腔医院复苏室,国家口腔医学中心,国家口腔疾病临床医学研究中心,口腔数字化医疗技术和材料国家工程实验室,北京 100081;
    3北京大学口腔医学院口腔医院种植科,国家口腔医学中心,国家口腔疾病临床医学研究中心,口腔数字化医疗技术和材料国家工程实验室,北京 100081
  • 收稿日期:2024-10-08 出版日期:2025-05-15 发布日期:2025-05-19
  • 通讯作者: *郑利光,男,硕士,主任药师,临床药学与药事管理。E-mail：Zhenglg1103@163.com
  • 作者简介:钱霞,女,硕士,主管药师,抗感染药学与临床药理学。

One Case of Taste Disorders Caused by Cetylpridinium Chloride Gargle

QIAN Xia1, ZHENG Liguang1,*, LI Tongtong2, HE Yachun3   

  1. 1Department of Pharmacy, Peking University School and Hospital of Stomatology, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing 100081, China;
    2Department of Resuscitation, Peking University School and Hospital of School, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing 100081, China;
    3Department of Implantation, Peking University School and Hospital of School, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing 100081, China
  • Received:2024-10-08 Online:2025-05-15 Published:2025-05-19

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摘要： 目的 探讨西吡氯铵含漱液在发挥其治疗作用同时避免味觉异常不良反应发生。方法 对1例使用西吡氯铵含漱液导致的味觉障碍病例进行讨论,结合国内外相关报道进行分析致味觉异常的原因和可能机制。结果 西吡氯铵含漱液致味觉异常较常见,应早发现早干预,尽快对症处理恢复患者味觉。结论 西吡氯铵含漱液致味觉异常发生率较高,临床应重视其不良反应,一旦患者发生味觉障碍,须及时停用,并对症处理。

关键词: 西吡氯铵, 含漱液, 味觉障碍, 味觉异常, 药品不良反应

Abstract: Objective To explore the therapeutic effect of cetylpirdinium chloride gargle while avoiding taste abnormalities and adverse reactions. Methods One case of taste disorder caused by cetylpirdinium chloride gargle was discussed. Based on a review of related reports at home and abroad, the cause of taste disorder and possible mechanisms were studied. Results Taste abnormalities caused by the use of cetylpirdinium chloride gargle were quite common globally. Early detection and interventions had to be carried out to restore taste. Conclusion The incidence of taste abnormalities caused by the use of cetylpirdinium chloride gargle remains relatively high. It is recommended that doctors and patients alike be aware of the likelihood of this adverse reaction. Once taste disorders occur, the drug should be discontinued quickly and symptomatic treatment initiated.

Key words: Cetylpirdinium, Chloride Gargle, Taste Disorder, Dysgeusia, Adverse Drug Reaction

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