中国药物警戒 ›› 2025, Vol. 22 ›› Issue (5): 580-582.
DOI: 10.19803/j.1672-8629.20240603

• 安全与合理用药 • 上一篇    下一篇

盐酸特拉唑嗪片致心房颤动1例分析

郭稳1,2, 邓智建2,3, 张永恒2,3, 郭锦辉2,3,*   

  1. 1辉县市人民医院药剂科,河南 辉县 453600;
    2新乡医学院第一附属医院临床药学学部,河南 卫辉 453100;
    3河南省医学重点学科,药学其他学科（临床药学）,新乡医学院第一附属医院,河南 卫辉 453100
  • 收稿日期:2024-06-03 出版日期:2025-05-15 发布日期:2025-05-19
  • 通讯作者: *郭锦辉,男,硕士,副主任药师,临床药学。E-mail:xxyxy@foxmail.com
  • 作者简介:郭稳,女,学士,主管药师,临床药学。
  • 基金资助:
    中国药学会2024年科普研究重点项目（CMEI2024-KPYJ00610）

One Case of Atrial Fibrillation Caused by Terazosin Tablets

GUO Wen1,2, DENG Zhijian2,3, ZHANG Yongheng2,3, GUO Jinhui2,3,*   

  1. 1Department of Pharmacy, Huixian People’s Hospital, Huixian Henan 453600, China;
    2Department of Clinical Pharmacy, the First Affiliated Hospital of Xinxiang Medical University, Weihui Henan 453100, China;
    3Clinical Pharmacy, Henan Province Key Subjects of Medicine, the First Affiliated Hospital of Xinxiang Medical University, Weihui Henan 453100, China
  • Received:2024-06-03 Online:2025-05-15 Published:2025-05-19

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摘要： 目的 探讨盐酸特拉唑嗪片致心房颤动的不良反应及其机制,为临床合理用药提供参考。方法 对1例使用盐酸特拉唑嗪片治疗高血压合并肾动脉狭窄的病例进行分析,并对相关文献进行归纳和总结。结果 1例52岁女性患者因头晕入院,诊断为脑梗死、高血压3级（极高危）、合并有房间隔膨出瘤、右肾动脉中度狭窄等,给予盐酸特拉唑嗪片1 mg口服后,患者出现心跳加快、心慌等,经心电图示心房颤动,给予美托洛尔缓释片47.5 mg口服,随后不适症状好转。经关联性评价,盐酸特拉唑嗪片致心房颤动为很可能。结论 心房颤动可能是盐酸特拉唑嗪片的潜在不良反应之一,临床治疗过程中,应详细询问患者既往病史、用药史,用药期间严密监测患者心电图等,同时应警惕再次给药后的再激发风险,确保患者用药安全。

关键词: 盐酸特拉唑嗪片, 心房颤动, 房间隔膨出瘤, 肾动脉狭窄, 药品不良反应

Abstract: Objective To explore the mechanism through which terazosin tablets induce atrial fibrillation (AF) in order to provide a reference for rational drug use in clinical practice. Methods One case of hypertension complicated with renal artery stenosis treated with terazosin tablets was analyzed based on a literature review. Results A 52-year-old female patient was admitted to the hospital due to dizziness and was diagnosed with cerebral infarction, stage 3 hypertension at extremely high risk, accompanied by atrial septal aneurysm and moderate stenosis of the right renal artery. She was administered 1 mg of terazosin tablets orally before she experienced such symptoms as rapid heartbeat and palpitations. An immediate electrocardiogram showed atrial fibrillation. She was given 47.5 mg of metoprolol sustained-release tablets orally, and her symptoms subsequently subsided. Based on correlation evaluation, it was speculated that the patient's atrial fibrillation might have been caused by terazosin tablets. Conclusion Atrial fibrillation may be one of the potential adverse reactions of terazosin tablets. Therefore, clinicians need to inquire about a patient's history of disease and previous medications, closely monitor the electrocardiogram, and be alert to the risk of recurrence upon re-administration.

Key words: Terazosin, Atrial Fibrillation, Atrial Septal Protrusion Tumor, Renal Artery Stenosis, Adverse Drug Reaction

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