硫辛酸注射液致血液系统异常1例分析

doi:10.19803/j.1672-8629.20240658

摘要/Abstract

摘要： 目的分析使用硫辛酸导致血液系统异常的不良反应,为其临床安全应用提供参考。方法通过探讨1例硫辛酸注射液导致血液系统异常的病例,结合检索分析同类文献报道提出用药建议。结果患者使用硫辛酸注射液后第14天出现白细胞计数、红细胞计数、血红蛋白水平降低,停用硫辛酸注射液并予利可君治疗,治疗后第3天,该3项指标较前回升。结论临床应关注硫辛酸对血液系统的不良反应,特别是病程较长、有多重用药情况时可能增加不良反应发生的风险。

关键词: 硫辛酸, 注射液, 血液系统异常, 白细胞, 红细胞, 血红蛋白, 药品不良反应

Abstract: Objective To investigate the adverse drug reactions relating to lipoic acid induced hematological abnormalities so as to provide a reference for its safe clinical applications. Methods One case of hematological abnormalities after injections of lipoic acid was analyzed, and related literature was retrieved to help find the proper medication. Results Fourteen days after lipoic acid injection, blood routine examination results of the patient showed decreased levels of white blood cells, red blood cells and hemoglobin. The lipoic acid injection was discontinued and replaced by leucogen tablets. Three days after treatment, levels of the three indicators mentioned above improved. Conclusion Clinicians should be alert to the potential adverse effects of lipoic acid on the hematological system, particularly in cases with longer disease durations and multiple medications, whose risk of adverse drug reactions may increase.

Key words: Lipoic Acid, Injection, Hematological Abnormalities, White Blood Cells, Red Blood Cells, Hemoglobin, Adverse Drug Reactions

中图分类号:

R972
R994.11

刘颖, 郭红叶, 杨毅恒, 金锐. 硫辛酸注射液致血液系统异常1例分析[J]. 中国药物警戒, 2025, 22(4): 456-459.

LIU Ying, GUO Hongye, YANG Yiheng, JIN Rui. One Case of Hematological Abnormalities Caused by Lipoic Acid Injection[J]. Chinese Journal of Pharmacovigilance, 2025, 22(4): 456-459.

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