中国药物警戒 ›› 2016, Vol. 13 ›› Issue (6): 364-366.

• 安全性评价与合理用药 • 上一篇    下一篇

137例甘露醇注射液不良反应分析

张歆1, 秦文明2, 翟淑越1   

  1. 1淄博市药品不良反应监测中心,山东 淄博 255020;
    2山东齐都药业有限公司,山东 淄博 255400
  • 收稿日期:2016-07-22 修回日期:2016-07-22 出版日期:2016-06-20 发布日期:2016-07-22
  • 作者简介:张歆,男,本科,主管药师,药品不良反应监测。

Analysis on 137 Cases of Adverse Drug Reactions of Mannitol Injection

ZHANG Xin1, QIN Wen-ming2, ZAI Shu-yue1   

  1. 1Zibo Municipal Center for ADR Monitoring, Shandong Zibo 255020, China;
    2Shandong Qidu Pharmaceutical Co., Ltd., Shandong Zibo 255400, China
  • Received:2016-07-22 Revised:2016-07-22 Online:2016-06-20 Published:2016-07-22

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摘要： 目的 分析甘露醇注射液临床常见的不良反应特点和规律,提出有效预防措施以保证患者用药安全。方法 对2015年7月1日~9月30日我市药品不良反应中心收集到的137例甘露醇注射液不良反应,按照人群性别与年龄、症状、累及系统-器官、发生时间、新的或严重的不良反应等方面进行分析。结果 137例甘露醇注射液不良反应多数发生于46岁以上患者,男性比例与女性比例相当;多数为高剂量使用患者;累及系统-器官主要为泌尿系统损害、皮肤及其附件损害、神经系统损害、全身性损害;不良反应发生时间多为用药后30 min内。结论 应进一步完善药品说明书中老年患者用法用量说明,关注特殊人群用药,规范临床用药并加强患者监护。

关键词: 甘露醇注射液, 药品不良反应

Abstract: Objective To analyze the common characteristics and rules of adverse drug reactions (ADRs) induced by mannitol injection, propose effective preventive measures of ADRs, and ensure medication safety of patients. Methods 137 cases of ADRs induced by mannitol injection from our center from July 1st, 2015 to September 30th, 2015 were analyzed in terms of genders and ages, symptoms, system-organs, time of occurring, new or serious ADRs. Results Most ADRs induced by mannitol injection occurred in patients over 46 years old, which happened equally between the male and the female. ADRs often occurred in patients with high doses. The main clinical manifestations of ADRs induced by mannitol injection involved urinary system disorders, skin and appendages disorders, nervous system disorders, and general disorders. ADRs mostly occurred within 30 min. Conclusion The usage and dosage in drug instructions for middle-old aged patients should be further improved, the medication of special groups should be paid more attention, clinical medication should be standardized and monitoring should be strengthened.

Key words: mannitol injection, adverse drug reaction

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