中国药物警戒 ›› 2016, Vol. 13 ›› Issue (6): 367-370.

• 安全性评价与合理用药 • 上一篇    下一篇

某院门诊质子泵抑制剂用药合理性分析

蒋军1, 夏宗玲1*, 王秋纯2   

  1. 1常州市第一人民医院,江苏 常州,213003;
    2徐州医科大学药学院,江苏 徐州,221004
  • 收稿日期:2016-07-22 修回日期:2016-07-22 出版日期:2016-06-20 发布日期:2016-07-22
  • 通讯作者: 夏宗玲,女,硕士,副主任药师,医院药学。E-mail：34301433@qq.com
  • 作者简介:蒋军,男,硕士,副主任药师,医院药学。
  • 基金资助:
    常州市科技局指导性项目常州四药科研基金（CS20109010）

Analysis of Utilization Rationality of Proton Pump Inhibitors in Prescriptions of Outpatients in a Hospital

JIANG Jun1, XIA Zong-ling1*, WANG Qiu-chun2   

  1. 1First People’s Hospital of Changzhou, Jiangsu Changzhou 213003, China;
    2 School of Pharmacy, Xuzhou Medical University, Jiangsu Xuzhou 221004, China
  • Received:2016-07-22 Revised:2016-07-22 Online:2016-06-20 Published:2016-07-22

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摘要： 目的 了解我院门诊质子泵抑制剂（PPIs）使用的合理性,规范PPIs的临床使用。方法 抽取2015年每月10号和20号两天含PPIs的门诊处方共4 392张,依据我院PPIs门诊处方点评标准分析评价用药指征、给药途径、溶媒选择、用法、用量与联合用药等方面的合理性。结果 抽查的4 392张处方中,不合理处方1 074张,不合理率24.39%。发现不合理情况1 145例,包括临床诊断与适应证不符合856例（74.46%）、联合用药不适宜191例（16.68%）、给药途径不恰当49例（4.28%）、溶媒选择不恰当47例（4.10%）、用法错误2例（0.17%）。结论 我院门诊使用PPIs存在一定程度的不合理现象。医生应严格把握适应证用药,药师在加强审方力度的同时,发现问题及时与医生沟通。

关键词: 质子泵抑制剂, 处方分析, 合理用药

Abstract: Objective To investgate the rationality of proton pump inhibitors (PPIs) use for outpatients in our hospital so as to regulate the rational clinical use of PPIs. Methods 4 392 outpatient prescriptions of PPIs were selected on the 10th and 20th of each month in 2015. The rationality of PPIs use was analyzed and evaluated in terms of indications, route of administration, solvent, usage, dosage, and combination of drugs by the standard of outpatient prescriptions for PPIs in our hospital. Results 1 074 irrational prescriptions were analyzed in 4 392 prescriptions, with irrationality ration of 24.39%. There are 1 145 unreasonable situations, including 856 cases of non-indicated use of drugs (accounting for 74.46%), 191 cases of improper combined use of drugs (accounting for 16.68%), 49 cases of inappropriate route of administration (accounting for 0.17%), 49 cases of solvent (accounting for 4.10%) and 2 cases of incorrect usage(accounting for 4.10%). Conclusion There exists an irrational situation of PPIs use in outpatients to a certain degree. Clinicians should master the indications of drug use seriously, pharmacists ought to pay more attention to censoring the prescriptions and contact with clinicians in time when discovering the irrational use of drugs.

Key words: proton pump inhibitor, prescription analysis, rational drug use

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