中药调控DNA甲基化研究进展

doi:10.19803/j.1672-8629.20260417

摘要/Abstract

摘要： 目的梳理中药调控DNA甲基化的研究现状,为中药作用机制研究和临床应用提供参考。方法检索中国知网、PubMed、Web of Science等数据库,对中药单体、有效部位/提取物、单味药、复方制剂及药性理论干预DNA甲基化的相关文献进行归纳、分析与综述。结果 DNA甲基化是重要的表观遗传调控方式,其异常与肿瘤、心血管疾病、代谢性疾病、慢性肾病、神经退行性疾病、骨质疏松等多种疾病密切相关。中药可通过调节DNA甲基转移酶、去甲基化酶及关键基因启动子甲基化水平发挥多靶点、多途径调控作用。结论中药调控DNA甲基化与中医药整体观、性味归经及配伍理论高度契合,基于DNA甲基化开展中药研究,有利于推动中医药发展。

关键词: DNA甲基化, 中药, 表观遗传, 调控, 机制

Abstract: Objective To review the recent advances in research on the role of traditional Chinese medicine (TCM) in regulating DNA methylation over the past three years so as to provide evidence for the elucidation of the mechanisms, rational clinical applications and pharmacovigilance related to TCM. Methods Such databases as CNKI, PubMed and Web of Science were searched. Literature about DNA methylation regulated by TCM monomers, effective parts/extracts, single herbs, compound preparations and property-meridian theories was summarized and analyzed. Results DNA methylation was an important epigenetic modification, the abnormality of which was closely related to such diseases as tumors, atherosclerosis, liver fibrosis, nephropathy, osteoporosis and aging. TCM exerted multi-target and multi-channel regulatory effects primarily by modulating DNA methyltransferases, demethylases and methylation levels of key gene promoters. Conclusion The regulation of DNA methylation by TCM is highly consistent with the holistic concept, nature-taste-meridian tropism and compatibility theory of TCM, which is why this sphere is promising. The development of pharmacovigilance and precise medication of TCM based on DNA methylation can contribute to the modernization and high-quality development of TCM.

Key words: DNA Methylation, Traditional Chinese Medicine, Epigenetics, Regulatory, Mechanism

中图分类号:

R282
R994.11

彭丽丽, 范燕, 田春华, 肖苏萍. 中药调控DNA甲基化研究进展[J]. 中国药物警戒, 2026, 23(9): 1065-1069.

Peng Lili, Fan Yan, Tian Chunhua, Xiao Suping. Research progress in the regulation of DNA methylation by traditional Chinese medicine[J]. Chinese Journal of Pharmacovigilance, 2026, 23(9): 1065-1069.

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https://zgywjj.magtechjournal.com/CN/Y2026/V23/I9/1065

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