[1] MEHROTRA N, SINGH S.Periodontitis[M]. FL:Treasure Island, 2025. [2] ARTAMONOV MY, MARTUSEVICH AK, PYATAKOVICH FA, et al.Molecular Hydrogen:From Molecular Effects to Stem Cells Management and Tissue Regeneration[J]. Antioxidants (Basel), 2023, 12(3):636. [3] JOHNSEN HM, HIORTH M, KLAVENESS J.Molecular Hydrogen Therapy-A Review on Clinical Studies and Outcomes[J]. Molecules, 2023, 28(23):7785. [4] JIMÉNEZ-JIMÉNEZ FJ, ALONSO-NAVARRO H, GARCÍA-MARTÍN E, et al. Oxidative Stress and Migraine[J]. Mol Neurobiol, 2024, 61(10):8344-8360. [5] BULLON P, GIAMPIERI F, BULLON B, et al. The Role of Oxidative Stress in Periodontitis[J/OL]. J Periodontal Res, (2025-07-17)[2026-03-20]. https://pubmed.ncbi.nlm.nih.gov/40671662/. [6] LOPEZ T, WENDREMAIRE M, LAGARDE J, et al.Wound Healing versus Metastasis:Role of Oxidative Stress[J]. Biomedicines, 2022, 10(11):2784. [7] ZHANG Y, CHEN J, WU H, et al.Hydrogen Regulates Mitochondrial Quality to Protect Glial Cells and Alleviates Sepsis-Associated Encepha-lopathy by Nrf2/YY1 Complex Promoting HO-1 Expression[J]. Int Immunopharmacol, 2023, 118:110009. [8] BEZERRA FS, LANZETTI M, NESI RT, et al.Oxidative Stress and Inflammation in Acute and Chronic Lung Injuries[J]. Antioxidants (Basel), 2023, 12(3):548. [9] YANG W, LI T, WAN Q, et al.Molecular Hydrogen Mediates Neurores-torative Effects after Stroke in Diabetic Rats:the TLR4/NF-κB Inflammatory Pathway[J]. J Neuroimmune Pharmacol, 2023, 18(1-2):90-99. [10] LIU L, WANG S, JIANG L, et al.Molecular Hydrogen Mitigates Traumatic Brain Injury-Induced Lung Injury via NLRP3 Inflammasome Inhibition[J]. BMC Chem, 2025, 19(1):138. [11] SAITOH Y, YONEKURA N, MATSUOKA D, et al.Molecular Hydrogen Suppresses Porphyromonas Gingivalis Lipopolysaccharide-Induced Increases in Interleukin-1 Alpha and Interleukin-6 Secretion in Human Gingival Cells[J]. Mol Cell Biochem, 2022, 477(1):99-104. [12] FAN Y, WANG J, FENG Z, et al.Hydrogen-Rich and Hyperoxygenated Saline Inhibits Lipopolysaccharide-Induced Lung Injury through Mediating NF-κB/NLRP3 Signaling Pathway in C57BL/6 Mice[J]. Environ Toxicol, 2022, 37(7):1575-1586. [13] HOU Z, ZHANG W, LI G, et al.Coaxial Fibrous Dressing Enabling Sequential NO/H2 Release for Temporally Programmed Antibacterial and Healing-Promoting Functions in Infected Diabetic Wound Trea-tment[J]. ACS Appl Mater Interfaces, 2025, 17(25):36497-36510. [14] LUI S, HSIEH T, LU J, et al.Predicting Therapeutic Response to Molecular Hydrogen in Autoimmune Diseases via Immunopheno-typing[J]. APMIS, 2025, 133(7):e70040. [15] AN P, ZHAO X, LIU M, et al.Gender-Based Differences in Neuro-protective Effects of Hydrogen Gas against Intracerebral Hemorrhage-Induced Depression[J]. Neurochem Int, 2022, 153:105276. [16] NEWTON K, STRASSER A, KAYAGAKI N, et al.Cell Death[J]. Cell, 2024, 187(2):235-256. [17] LI T, SUN T, WANG Y, et al.Molecular Hydrogen Alleviates Lung Injury after Traumatic Brain Injury:Pyroptosis and Apoptosis[J]. Eur J Pharmacol, 2022, 914:174664. [18] XU L, GUO W, DAI J, et al.Hydrogen Gas Alleviates Acute Ethanol-Induced Hepatotoxicity in Mice via Modulating TLR4/9 Innate Immune Signaling and Pyroptosis[J]. Int Immunopharmacol, 2024, 127:111399. [19] HE Q, LAN X, DING M, et al.Long-Term Consumption of Hydrogen-Rich Water Provides Hepatoprotection by Improving Mitochondrial Biology and Quality Control in Chronically Stressed Mice[J]. PLoS One, 2025, 20(2):e0317080. [20] QIAN Z, XIANZHI L, SHIYANG L, et al.Molecular Mechanisms Associated with Effects of Hydrogen Molecule in Liver Diseases:The Review of Current Evidence[J]. Eur J Med Res, 2025, 30(1):1074. [21] GUO J, TIAN S, WANG Z, et al.Hydrogen Saline Water Accelerates Fracture Healing by Suppressing Autophagy in Ovariectomized Rats[J]. Front Endocrinol (Lausanne), 2022, 13:962303. [22] JIN J, YUE L, DU M, et al.Molecular Hydrogen Therapy:Mechanisms, Delivery Methods, Preventive, and Therapeutic Application[J]. MedComm(2020), 2025, 6(5):e70194. [23] WANG M, YI Y, SUN MT, et al.Biomedical Research Progress of Hydrogen-Rich Water and Hydrogen-Rich Saline:Animal Experiment[J]. Current Biotechnology(生物技术进展), 2022, 12(3):332-343. [24] LI Y, ZHANG Z, YAO Y, et al.Hetero-Structured Ru-Mo2C Nanoparticles Loaded on N,P Co-Doped Carbon for a pH Universal Hydrogen Evolution Reaction[J]. Dalton Trans, 2024, 53(43):17581-17587. [25] WANG P, WU J, YANG H, et al.Intelligent Microneedle Patch with Prolonged Local Release of Hydrogen and Magnesium Ions for Diabetic Wound Healing[J]. Bioact Mater, 2023, 24:463-476. [26] XIAO W, HE K, YU C, et al.Space Station-Like Composite Nanoparticles for Co-Delivery of Multiple Natural Compounds from Chinese Medicine and Hydrogen in Combating Sensorineural Hearing Loss[J]. Mol Pharm, 2023, 20(8):3987-4006. [27] YONEDA T, TOMOFUJI T, KUNITOMO M, et al.Preventive Effects of Drinking Hydrogen-Rich Water on Gingival Oxidative Stress and Alveolar Bone Resorption in Rats Fed a High-Fat Diet[J]. Nutrients, 2017, 9(1):64. [28] KASUYAMA K, TOMOFUJI T, EKUNI D, et al.Hydrogen-Rich Water Attenuates Experimental Periodontitis in a Rat Model[J]. J Clin Periodontol, 2011, 38(12):1085-1090. [29] EKUNI D, TOMOFUJI T, ENDO Y, et al.Hydrogen-Rich Water Prevents Lipid Deposition in the Descending Aorta in a Rat Periodontitis Model[J]. Arch Oral Biol, 2012, 57(12):1615-1622. [30] TOMOFUJI T, KAWABATA Y, KASUYAMA K, et al.Effects of Hydrogen-Rich Water on Aging Periodontal Tissues in Rats[J]. Sci Rep, 2014, 4:5534. [31] SHI Y, JIN S, ZHENG H, et al.Hydrogen Rich Water Attenuates Pregnancy Gingivitis Induced by Ligation in SD Rats[J]. Shanghai Journal of Stomatology(上海口腔医学), 2018, 27(3):252-256. [32] TAMAKI N, ORIHUELA-CAMPOS RC, FUKUI M, et al.Hydrogen-Rich Water Intake Accelerates Oral Palatal Wound Healing via Activation of the Nrf2/Antioxidant Defense Pathways in a Rat Model[J]. Oxid Med Cell Longev, 2016, 2016:5679040. [33] ZHAO YW.Preliminary Study on the Effect of Hydrogen-Rich Water on Peri-Implant Inflammation[D]. Guangzhou:Southern Medical University, 2022. [34] ZHOU M, WANG Z.Protective Effects of Hydrogen-Rich Medium on Lipopolysaccharides-Induced Injury in Human Periodontal Ligament Cells[J]. West China Journal of Stomatology(华西口腔医学杂志), 2018, 36(2):123-127. [35] NAYAK A, BHATT A, BHAT K, et al.Assessment of Antibacterial Effect of Hydrogen Water on Plaque from Patients with Chronic Periodontitis[J]. J Indian Soc Periodontol, 2021, 25(3):193-196. [36] WANG D, SHIMAMURA N, MIWA N, et al.Combined Use of Hydrogen-Rich Water and Enzyme-Digested Edible Bird’s Nest Improves PMA/LPS-Impaired Wound Healing in Human Inflammatory Gingival Tissue Equivalents[J]. Hum Cell, 2024, 37(4):997-1007. [37] VAISHNAVI C, ELANGOVAN GP, THIRUMAL M, et al.Comparison of the Antimicrobial Effect of Hydrogen Water and Chlorhexidine Mouth Rinse in Toothbrush Disinfection Among Dental Students[J]. J Pharm Bioallied Sci, 2025, 17(Suppl 1):528-530. [38] AZUMA T, YAMANE M, EKUNI D, et al.Drinking Hydrogen-Rich Water Has Additive Effects on Non-Surgical Periodontal Treatment of Improving Periodontitis:a Pilot Study[J]. Antioxidants (Basel), 2015, 4(3):513-522. [39] YING J, ZHANG K, HUANG Y, et al.Molecular Hydrogen:Mechanism Against Oxidative Stress and Application in Periodontitis:a Review[J]. Medicine (Baltimore), 2025, 104(10):e41800. |