中国药物警戒 ›› 2026, Vol. 23 ›› Issue (5): 595-599.
DOI: 10.19803/j.1672-8629.20250937

• 综述 • 上一篇    下一篇

分子氢在牙周疾病治疗中的作用研究进展

于凤新1, 代春丽1, 贾森2,*   

  1. 1海军青岛特勤疗养中心疗养三区,山东 青岛 266071;
    2陕西中医药大学第二附属医院口腔科,陕西 咸阳 712000
  • 收稿日期:2025-12-29 发布日期:2026-05-20
  • 通讯作者: *贾森,男,博士,主治医师,口腔医学与药物学。E-mail: jiasen1119@163.com
  • 作者简介:于凤新,女,本科,主管护师,氢医学。
  • 基金资助:
    陕西省自然科学基金资助项目(2025JC-YBMS-631)

Research Progress in the Role of Molecular Hydrogen in the Treatment of Periodontal Diseases

YU Fengxin1, DAI Chunli1, JIA Sen2,*   

  1. 1The Third Region, Navy Qingdao Special Service Rehabilitation Center, Qingdao Shandong 266071, China;
    2Department of Stomatology, Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Xianyang Shaanxi 712000, China
  • Received:2025-12-29 Published:2026-05-20

摘要: 目的 探讨分子氢(H2)的作用机制、给药方式及其在牙周疾病治疗中的研究进展,为H2的临床应用提供参考。方法 查阅文献和总结H2的分子作用机制与给药方式,综述其在牙周疾病治疗中的应用现状,并分析其疗效。结果 H2具有显著的抗氧化、抗炎和抗凋亡作用; 临床应用中,通过饮用富氢水等方式可有效促进牙周疾病的治疗。结论 H2在牙周疾病防治中具有潜在作用,但仍需更多深入研究以进一步明确其疗效和安全性。

关键词: 分子氢, 牙周疾病, 给药方式, 抗氧化, 抗炎, 机制

Abstract: Objective To explore the mechanisms and administration methods of molecular hydrogen (H2) and to summarize the research progress in the treatment of periodontal diseases with H2. Methods Related literature was reviewed to summarize the molecular mechanisms and routes of administration of H2 as well as the current applications and therapeutic effects of H2 in the treatment of periodontal diseases. Results H2 possessed significant antioxidant, antiinflammatory, and anti-apoptotic properties. Clinically, the consumption of hydrogen-rich water could effectively facilitate the treatment of periodontal diseases. Conclusion H2 promises good potential in the prevention and treatment of periodontal disease. However, more in-depth studies are required to establish its efficacy and safety.

Key words: Molecular Hydrogen (H2), Periodontal Disease, Administration Methods, Antioxidant, Anti-Inflammatory, Mechanism

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