中药调控多信号通路和肠道菌群治疗胃溃疡的整合机制研究进展

doi:10.19803/j.1672-8629.20260280

摘要/Abstract

摘要： 目的系统综述中药通过调控多信号通路及肠道菌群,最终实现二者相互作用协同治疗胃溃疡的整合机制,为临床研究提供参考。方法检索并分析近年来关于中药调控胃溃疡相关的信号通路,以及调节肠道菌群结构与功能的相关研究,重点归纳其对炎症反应和胃黏膜修复的作用机制。结果中药不仅能通过调控多信号通路,减轻炎症反应,促进胃黏膜上皮细胞增殖与修复;还能够调节肠道菌群组成,恢复菌群生态平衡,增强黏膜屏障功能。信号通路与肠道菌群之间存在交互调控,形成协同修复的整合网络。结论中药通过多靶点、多通路及肠道菌群调节的整合机制治疗胃溃疡,为后续研究提供新的思路。

关键词: 中药, 胃溃疡, 信号通路, 肠道菌群, 整合机制

Abstract: Objective To review the integrative mechanisms by which Traditional Chinese Medicine combats gastric ulcer by regulating multiple signaling pathways and gut microbiota and inducing synergistic interactions between these two systems so as to provide data for clinical research. Methods Related databases were searched for studies published in recent years on the regulation of signaling pathways related to gastric ulcer and to the modulation of gut microbiota structure and function mediated by Traditional Chinese Medicine. The included studies were analyzed by focusing on the mechanisms underlying inflammatory responses and gastric mucosal repair. Results By regulating multiple signaling pathways, Traditional Chinese Medicine can not only alleviate inflammation and promote the proliferation and repair of gastric mucosal epithelial cells, but also modulate gut microbiota composition, restore microbial homeostasis, and enhance mucosal barrier function. Bidirectional interactions were observed between signaling pathways and gut microbiota, forming an integrated network that contributed to synergistic mucosal repair. Conclusion Traditional Chinese Medicine can be used to treat gastric ulcer through integrative mechanisms involving multiple targets, multiple pathways, and gut microbiota regulation. This study is expected to offer new lines of thought for future research.

Key words: Traditional Chinese Medicine, Gastric Ulcer, Signal Pathway, Intestinal Flora, Integration Mechanism

中图分类号:

R975.6
R285

张旭强, 董寿堂, 王怀斌, 龚晓敏, 李维俊, 杨红芹. 中药调控多信号通路和肠道菌群治疗胃溃疡的整合机制研究进展[J]. 中国药物警戒, 2026, 23(8): 954-959.

Zhang Xuqiang, Dong Shoutang, Wang Huaibin, Gong Xiaomin, Li Weijun, Yang Hongqin. Research progress in the integrated mechanism of traditional Chinese medicine against gastric ulcer by regulating multiple signaling pathways and intestinal flora[J]. Chinese Journal of Pharmacovigilance, 2026, 23(8): 954-959.

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