口服复方聚乙二醇电解质散（Ⅱ）肠道准备致呕血2例分析

doi:10.19803/j.1672-8629.20260120

中国药物警戒 ›› 2026, Vol. 23 ›› Issue (8): 931-933.
DOI: 10.19803/j.1672-8629.20260120

口服复方聚乙二醇电解质散（Ⅱ）肠道准备致呕血2例分析

张育茂¹, 刘君波¹, 罗千江², 谭槟滢³, 邓彬⁴, 邢惟青^3#, 李玉珍^1,*

¹中山大学附属第八医院药学部,广东深圳 518033;
²中山大学附属第八医院消化内科,广东深圳 518033;
³深圳市药物警戒和风险管理研究院,广东深圳 518000;
⁴广东省药品不良反应监测中心,广东广州 510080

收稿日期:2026-02-10 出版日期:2026-08-15 发布日期:2026-08-17
通讯作者: ^*李玉珍,女,硕士,主任药师·硕导,医院药事管理。E-mail: liyzh56@mail.sysu.edu.cn^#为共同通信作者。
作者简介:张育茂,男,博士,主管药师,药物警戒与临床药学。
基金资助:
福田区卫生健康系统科研项目（FTWS001）; 福田区卫生健康系统科研项目（FTWS2023088）

Two cases of hematemesis caused by polyethylene glycol electrolytes powder (Ⅱ) during bowel preparation

Zhang Yumao¹, Liu Junbo¹, Luo Qianjiang², Tan Binying³, Deng Bin⁴, Xing Weiqing^3#, Li Yuzhen^1,*

¹Department of Pharmacy, the Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen Guangdong 518033, China;
²Department of Gastroenterology, the Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen Guangdong 518033, China;
³Shenzhen Institute of Pharmacovigilance and Risk Management, Shenzhen Guangdong 518000, China;
⁴Guangdong Adverse Drug Reaction Monitoring Center, Guangzhou Guangdong 510080, China

Received:2026-02-10 Online:2026-08-15 Published:2026-08-17

摘要/Abstract

摘要： 目的探讨复方聚乙二醇电解质散（Ⅱ）用于肠道准备过程时致呕血的临床特征、可能机制及危险因素,为临床安全用药提供参考。方法对2例使用复方聚乙二醇电解质散（Ⅱ）后出现剧烈呕吐引起呕血的病例进行分析,结合文献分析机制、不良反应关联性、潜在诱因及预防措施。结果经关联性分析,2例患者呕血均很可能与使用复方聚乙二醇电解质散（Ⅱ）相关,经停药、抑酸、对症处理后症状缓解,预后良好。结论复方聚乙二醇电解质散总体安全性良好,但部分患者可因服药引发剧烈呕吐,甚至呕血,有时可出现食管贲门黏膜撕裂综合征。用药前评估患者危险因素,控制服药速度,预防剧烈呕吐的出现,保障临床用药安全。

关键词: 复方聚乙二醇电解质散（Ⅱ）, 肠道准备, 呕血, 食管贲门黏膜撕裂综合征, 药品不良反应

Abstract: Objective To analyze the clinical characteristics of hematemesis induced by polyethylene glycol electrolytes powder (Ⅱ) for bowel preparation, explore the possible mechanisms and risk factors, and provide references for safe clinical medication. Methods Two cases of hematemesis due to severe vomiting after administration were retrospectively analyzed. Based on a literature review, the mechanisms, causality, potential triggers, and preventive measures were explored. Results Correlation analysis showed that hematemesis was associated with polyethylene glycol electrolytes powder (Ⅱ) in these two patients. Symptoms improved after drug discontinuation, acid suppression and symptomatic treatment with favorable prognosis. Conclusion Despite its safety, polyethylene glycol electrolytes powder may cause severe vomiting, hematemesis or even Mallory-Weiss Syndrome. Physicians should evaluate risk factors beforehand and control administration speed to prevent severe vomiting and ensure safe medication.

Key words: Polyethylene Glycol Electrolytes Powder (Ⅱ), Bowel Preparation, Hematemesis, Mallory-Weiss Syndrome (MWS), Adverse Drug Reaction

中图分类号:

张育茂, 刘君波, 罗千江, 谭槟滢, 邓彬, 邢惟青, 李玉珍. 口服复方聚乙二醇电解质散（Ⅱ）肠道准备致呕血2例分析[J]. 中国药物警戒, 2026, 23(8): 931-933.

Zhang Yumao, Liu Junbo, Luo Qianjiang, Tan Binying, Deng Bin, Xing Weiqing, Li Yuzhen. Two cases of hematemesis caused by polyethylene glycol electrolytes powder (Ⅱ) during bowel preparation[J]. Chinese Journal of Pharmacovigilance, 2026, 23(8): 931-933.

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参考文献

[1] Jacobson B C, Anderson J C, Burke C A, et al.Optimizing bowel preparation quality for colonoscopy: consensus recommendations by the US multi-society task force on colorectal cancer[J]. American Journal of Gastroenterology, 2025, 120(4): 738-764.
[2] Areia M, Esposito G, Leclercq P, et al.Performance measures for upper gastrointestinal endoscopy: a European Society of Gastrointestinal Endoscopy (ESGE) quality improvement initiative-update 2025[J]. Endoscopy, 2025, 57(11): 1268-1297.
[3] Ye Hong, Zhao Yun.A case report of Mallory-Weiss syndrome caused by compound polyethylene glycol electrolyte powder[J]. Herald of Medicine(医药导报), 2006, 25(9): 971.
[4] Xiao Qili.Mallory-Weiss syndrome caused by oral compound polye-thylene glycol electrolyte powder: a case report[J]. Modern Diagnosis and Treatment(现代诊断与治疗), 2017, 28(22): 4285-4286.
[5] Jia Zhengwo, Shen Jingen, Zhang Xicheng, et al.A case report of Mallory-Weiss syndrome caused by bowel preparation with oral Compound Polyethylene Glycol Electrolyte powder (Ⅱ)[J]. Zhongguo Xiangcun Yiyao(中国乡村医药), 2022, 29(16): 51.
[6] Brinberg D E, Stein J.Mallory-Weiss tear with colonic lavage[J]. Annals of Internal Medicine, 1986, 104(6): 894-895.
[7] Hroncich M E.Colonoscopy preparation complicated by Mallory-Weiss tear[J]. Southern Medical Journal, 1992, 85(3): 328.
[8] Raymond P L.Mallory-Weiss tear associated with polyethylene glycol electrolyte lavage solution[J]. Gastrointestinal Endoscopy, 1991, 37(3): 410-411.
[9] Schwartz T.Polyethylene glycol electrolyte lavage solution-induced Mallory-Weiss tear[J]. Gastroenterology Nursing, 1995, 18(6): 233-234.
[10] Santoro M J, Chen Y K, Collen M J.Polyethylene glycol electrolyte lavage solution-induced Mallory-Weiss tears[J]. American Journal of Gastroenterology, 1993, 88(8): 1292-1293.
[11] Liu Min, Wang Haixue.Overview of causality evaluation methods for adverse reactions in drug clinical trials and consideration of existing problems[J]. The Chinese Journal of Clinical Pharmacology(中国临床药理学杂志), 2023, 39(8): 1206-1211.
[12] Gelrud A. Mallory-Weiss syndrome[DB/OL]. Laine L, ed. UpToDate. Wolters Kluwer. (2025-12-22)[2026-01-05]. https://www.uptodate.com/contents/mallory-weiss-syndrome.
[13] Mertens A, Essing T, Roderburg C, et al.A systematic analysis of incidence, therapeutic strategies, and in-hospital mortality of Mallory-Weiss syndrome in Germany[J]. Journal of Clinical Gastroenterology, 2024, 58(7): 640-649.
[14] Hassanein M, Larue K, Sani A, et al.Efficacy and safety of mono-polar coagulation forceps in the repair of large Mallory-Weiss tear in patients with massive upper gastrointestinal bleeding, 2 case reports[J]. American Journal of Internal Medicine, 2025, 13(2): 11-15.
[15] Kortas D Y, Haas L S, Simpson W G, et al.Mallory-Weiss tear: predisposing factors and predictors of a complicated course[J]. American Journal of Gastroenterology, 2001, 96(10): 2863-2865.
[16] Hu Z, Liu D.Mallory-Weiss syndrome[J]. New England Journal of Medicine, 2024, 390(20): e49.
[17] Huang L, Li C, Jiang Y Z, et al.Vitamin drinks improve palatability and reduce adverse events associated to polyethylene glycol electrolyte solutions[J]. Heliyon, 2024, 10(17): e37590.
[18] Bednarska O, Nyhlin N, Schmidt P T, et al.The effectiveness and tolerability of a very low-volume bowel preparation for colonoscopy compared to low and high-volume polyethylene glycol-solutions in the real-life setting[J]. Diagnostics (Basel), 2022, 12(5), 1155.
[19] Yan X J, Xu P, Qiu H Y, et al.Antiemetics improve the tolerance of polyethylene glycol for colonoscopy preparation: a randomized clinical trial[J]. Medicine (Baltimore), 2021, 100(10): e24947.

口服复方聚乙二醇电解质散（Ⅱ）肠道准备致呕血2例分析

Two cases of hematemesis caused by polyethylene glycol electrolytes powder (Ⅱ) during bowel preparation

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