214例肌苷注射液不良反应报告分析

doi:10.19803/j.1672-8629.20260111

摘要/Abstract

摘要： 目的分析肌苷注射液不良反应发生特点,为临床安全用药提供参考,提高医务人员合理用药。方法收集2004年1月1日至2025年12月31日云南省药品不良反应监测系统中关于肌苷注射液的报告共214例,对患者性别、年龄、不良反应累及系统-器官及临床表现、用药原因、配伍/合并用药情况、不良反应发生时间进行统计分析。结果 214例不良反应报告中,男女性别比为0.57∶1,多发生于65岁及以上老年患者。57例（26.64%）患者的原患疾病是说明书未记载的适应证。配伍用药以电解质、酸碱平衡及营养药、酶类及其他生化药为主（113例,52.80%）。不良反应发生时间多为用药后30 min内（65.42%）,不良反应主要累及皮肤及皮下组织、全身及给药部位、胃肠系统,可引起寒战、高热、呼吸困难、心悸、紫癜、类过敏反应、超敏反应和过敏性休克等新的严重药品不良反应。结论临床应警惕肌苷注射液引起的严重不良反应,规范临床用药,加强老年患者用药监护,及早识别处理过敏性休克等严重不良反应。

关键词: 肌苷注射液, 过敏性休克, 过敏样反应, 合理用药, 药品不良反应

Abstract: Objective To analyze the characteristics of adverse drug reactions (ADRs) induced by inosine injection and provide references for safe medications. Methods A total of 214 cases of ADRs induced by inosine injection collected in 2004-2025 were retrieved from the Adverse Drug Reaction Monitoring System of Yunnan Province. Statistical analysis was conducted of the patients’ gender, age, systems-organs involved and clinical manifestations, indications for medication, combined medications, and onset time of ADRs. Results The male-to-female ratio was 0.57:1. Most of the adverse reactions caused by inosine for injection occurred in patients over 65 years old. The primary diseases were indications that were not recorded in package inserts in 57 patients (26.64%). Combined medications included electrolyte/acid-base balance/ nutrition agents, enzymes and other biochemical agents (113 cases, 52.80%). Adverse reactions usually started within 30 minutes of medication. ADRs primarily involved the skin and appendages, the whole body, sites of injection and the gastrointestinal system. The new serious clinical manifestations were rigors, hyperpyrexia, dyspnea, palpitations, anaphylactoid reaction, purpura, anaphylactic shock and hypersensitivity. Conclusion Clinicians should be alert to ADRs caused by inosine for injection in clinical practice, standardize clinical medications, and prevent such serious adverse reactions as anaphylaxis.

Key words: Inosine Injection, Anaphylaxis Shock, Anaphylactoid Reaction, Rational Drug Use, Adverse Drug Reaction

中图分类号:

R977
R994.11

白丽琴, 聂红科, 杨淑婷, 蒋晓峰. 214例肌苷注射液不良反应报告分析[J]. 中国药物警戒, 2026, 23(8): 909-913.

Bai Liqin, Nie Hongke, Yang Shuting, Jiang Xiaofeng. 214 cases of adverse drug reactions caused by inosine injection[J]. Chinese Journal of Pharmacovigilance, 2026, 23(8): 909-913.

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