中国药物警戒 ›› 2026, Vol. 23 ›› Issue (10): 1178-1180.
DOI: 10.19803/j.1672-8629.20260370

• 安全与合理用药 • 上一篇    下一篇

雷贝拉唑肠溶片致药物超敏反应综合征1例分析

黄春美, 于彩霞, 杨丽萍*   

  1. 自贡市第三人民医院临床药学室,四川 自贡 643020
  • 收稿日期:2026-05-08 出版日期:2026-10-15 发布日期:2026-10-16
  • 通讯作者: *杨丽萍,女,硕士,主任药师,医院管理与临床药学。E-mail: 648927759@qq.com
  • 作者简介:黄春美,女,硕士,副主任药师,临床药学。

One case of drug-induced hypersensitivity syndrome caused by rabeprazole enteric-coated tablets

Huang Chunmei, Yu Caixia, Yang Liping*   

  1. Clinical Pharmacy Office, the Third People’s Hospital of Zigong City, Zigong Sichuan 643020, China
  • Received:2026-05-08 Online:2026-10-15 Published:2026-10-16

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摘要： 目的 分析雷贝拉唑肠溶片所致药物超敏反应综合征（DIHS）的临床特点、发病机制,为临床安全用药提供参考。方法 探讨1例过敏体质患者口服雷贝拉唑钠肠溶片后,先后出现高热、全身皮疹、多脏器损伤（肝、骨骼肌、心肌、肺）的DIHS病例,梳理其诊治过程并结合相关文献开展分析。结果 患者经停用雷贝拉唑肠溶片,予以相应治疗后全身症状逐渐消退,脏器损伤指标持续好转,治愈出院。结合患者用药时序、临床表现、停药后病情改善情况,综合判定雷贝拉唑肠溶片致DIHS为“很可能”。结论 雷贝拉唑肠溶片可诱发罕见但危及生命的 DIHS,过敏体质者风险更高。临床应加强用药监测,坚持早停药、早诊断、规范激素治疗,提高安全用药水平。

关键词: 雷贝拉唑肠溶片, 质子泵抑制剂, 药物超敏反应综合征, 药品不良反应

Abstract: Objective To analyze the clinical characteristics, pathosis, and diagnosis and treatment of drug-induced hypersensitivity syndrome (DIHS) caused by rabeprazole enteric-coated tablets in order to provide a reference for safe clinical medications. Methods We reported a case of allergic diathesis in a patient who developed successive high fever, generalized rash and multiple organ injuries (the liver, skeletal muscle, myocardium, lung) after taking oral rabeprazole sodium enteric-coated tablets. The diagnostic and treatment process was summarized and analyzed based on literature. Results After rabeprazole enteric-coated tablets were discontinued, the systemic symptoms of the patient were attenuated, and indicators of organ damage recovered steadily. The patient was discharged after being clinically cured. Given the medication sequence, clinical manifestations and improvement after drug withdrawal, the causality between rabeprazole enteric-coated tablets and DIHS was considered “probable”. Conclusion Rabeprazole enteric-coated tablets can induce rare but life-threatening DIHS, with the risk higher in individuals with allergic constitutions. Clinicians should strengthen drug monitoring while adhering to early discontinuation of the drug, early diagnosis, and standardized hormone therapy to ensure safe medication.

Key words: Rabeprazole Enteric-Coated Tablets, Proton Pump Inhibitors, Drug-Induced Hypersensitivity Syndrome, Adverse Drug Reaction

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