地高辛片致舞蹈症1例分析

doi:10.19803/j.1672-8629.20250609

中国药物警戒 ›› 2026, Vol. 23 ›› Issue (9): 1059-1061.
DOI: 10.19803/j.1672-8629.20250609

地高辛片致舞蹈症1例分析

王昆^1,2, 徐磊², 汪岑^1,2, 侯文平³, 刘俊保^2#, 苏长海^1,2,*

¹内蒙古科技大学包头医学院药学院,内蒙古包头 014040;
²鄂尔多斯市中心医院药剂科,内蒙古鄂尔多斯 017000;
³郴州市第四人民医院药剂科,湖南郴州 423000

收稿日期:2025-08-29 出版日期:2026-09-15 发布日期:2026-09-15
通讯作者: ^*苏长海,男,博士,主任药师•硕导,合理用药与循证药学。E-mail：suchang2180@sina.com。^#为共同通信作者。
作者简介:王昆,男,硕士,临床药学。
基金资助:
鄂尔多斯市财政资助医学重点学科建设项目鄂卫健发（[2020]230号）

One case of chorea caused by digoxin tablets

Wang Kun^1,2, Xu Lei², Wang Cen^1,2, Hou Wenping³, Liu Junbao^2#, Su Changhai^1,2,*

¹School of Pharmacy,Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou Inner Mongolia 014040, China;
²Department of Pharmacy, Ordos Central Hospital, Ordos Inner Mongolia 017000, China;
³Department of Pharmacy, Chenzhou Fourth People's Hospital, Chenzhou Hunan 423000, China

Received:2025-08-29 Online:2026-09-15 Published:2026-09-15

摘要/Abstract

摘要： 目的探讨地高辛致舞蹈症病例,为临床安全合理用药提供参考。方法分析1例慢性肾病5期长期血液透析患者,因冠状动脉内支架植入术后再次心力衰竭服用地高辛后出现舞蹈症病例过程,检索相关文献并讨论其关联性及其可能机制。结果监测该例患者地高辛血药浓度为4.1 ng·mL^-1,结合Naranjo's因果关系评估,考虑地高辛致舞蹈症可能性大,停药给予以地西泮镇静治疗后,患者未再出现相关不良反应。结论地高辛致舞蹈症的危险因素主要源于地高辛蓄积中毒,临床使用中及时发现早期中毒症状,对于肾功能不全、合用与地高辛相互作用药物和特殊人群使用时应注意给药剂量并及时监测血药浓度,促进临床安全合理用药。

关键词: 地高辛, 舞蹈症, 中毒, 肾功能不全, 冠状动脉内支架植入术, 心力衰竭, 药品不良反应

Abstract: Objective To investigate one case of chorea induced by digoxin toxicity in order to provide a reference for safe and rational medication. Methods A patient with stage 5 chronic kidney disease undergoing long-term haemodialysis developed chorea following digoxin administration for recurrent heart failure after coronary stent implantation. Related literature was collected and the association between chorea and digoxin as well as its potential mechanisms were studied. Results The plasma concentration of digoxin was found to be 4.1 ng·mL^-1. Based on the Naranjo's Causality Index, digoxin-induced chorea was considered probable. Discontinuation of digoxin and administration of diazepam for sedation resulted in the absence of subsequent adverse reactions. Conclusion Risk factors for digoxin-induced chorea primarily stem from digoxin accumulation and toxicity. Early detection of digoxin toxicity is crucial in clinical practice. Particular attention should be paid to dosage adjustment and regular monitoring of serum concentrations in patients with renal impairment, those concurrently taking drugs interacting with digoxin, and special populations to ensure safe and rational clinical use.

Key words: Digoxin, Chorea, Poisoning, Renal Impairment, Coronary Stent Implantation, Heart Failure, Adverse Drug Reaction

中图分类号:

R972
R994.11

王昆, 徐磊, 汪岑, 侯文平, 刘俊保, 苏长海. 地高辛片致舞蹈症1例分析[J]. 中国药物警戒, 2026, 23(9): 1059-1061.

Wang Kun, Xu Lei, Wang Cen, Hou Wenping, Liu Junbao, Su Changhai. One case of chorea caused by digoxin tablets[J]. Chinese Journal of Pharmacovigilance, 2026, 23(9): 1059-1061.

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地高辛片致舞蹈症1例分析

One case of chorea caused by digoxin tablets

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