中国药物警戒 ›› 2024, Vol. 21 ›› Issue (6): 700-702.
DOI: 10.19803/j.1672-8629.20230610

• 安全与合理用药 • 上一篇    下一篇

甲苯磺酸多纳非尼片致多形红斑型药疹1例分析

唐祯菊1, 龙小换1, 王意军2, 黄愉腾1, 王卫亮2,*   

  1. 1广东医科大学第一临床医学院,广东 湛江 524023;
    2广东医科大学附属阳江医院皮肤科,广东 阳江 529500
  • 收稿日期:2023-09-27 出版日期:2024-06-15 发布日期:2024-06-18
  • 通讯作者: *王卫亮,男,硕士,主任医师,皮肤病与性病学。E-mail:13751641793@163.com
  • 作者简介:唐祯菊,女,在读硕士,住院医师,皮肤病与性病学。

One case of erythema multiforme drug eruption caused by donafenib tosilate tablets

TANG Zhenju1, LONG Xiaohuan1, WANG Yijun2, HUANG Yuteng1, WANG Weiliang2,*   

  1. 1The First Clinical School of Medicine, Guangdong Medical University, Zhanjiang Guangdong 524023, China;
    2Department of Dermatology, Yangjiang Hospital Affiliated to Guangdong Medical University, Yangjiang Guangdong 529500, China
  • Received:2023-09-27 Online:2024-06-15 Published:2024-06-18

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摘要： 目的 探讨甲苯磺酸多纳非尼片（简称“多纳非尼”）罕见全身皮肤不良反应临床特征及发生机制。方法 对1例胆囊恶性肿瘤患者应用多纳非尼致罕见皮肤毒性病例分析,结合相关文献,分析临床表现及发生机制。结果 患者主要表现为全身散在非典型靶形红斑、瘙痒、发热,与多形红斑型药疹的临床表现相似,予停用多纳非尼,使用激素、人免疫球蛋白、抗组胺治疗后症状明显缓解。结论 多纳非尼致多形红斑型药疹罕见且严重,应引起重视,目前国内外尚未有相关报道,多纳非尼为索拉非尼衍生物,考虑其发生机制与其相似。

关键词: 多纳非尼, 甲苯磺酸多纳非尼片, 药品不良反应, 多形红斑, 药疹, 皮肤, 胆囊恶性肿瘤

Abstract: Objective To explore the clinical characteristics and mechanism of rare systemic skin adverse reactions caused by donafenib tosilate tablets (donafenib). Methods Rare skin toxicity caused by donafenib in a patient with gallbladder malignant tumor was analyzed while the manifestations and pathogenesis were summarized based on literature review. Results The clinical manifestations of this patient including atypical target erythema, pruritus and fever were similar to those of erythema multiforme drug eruption. After discontinuation of donafenib and treatment with hormone, human immunoglobulin and antihistamine drugs, the symptoms were significantly relieved. Conclusion Erythema multiforme drug eruption induced by donafenib is rare but severe, which deserves more attention. There have been no related reports at home and abroad. Donafenib is a derivative of sorafenib so that the pathogenesis is similar.

Key words: donafenib, donafenib tosilate tablets, adverse drug reaction, erythema multiforme, drug eruption, cutaneous, gallbladder malignant tumor

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