中国药物警戒 ›› 2019, Vol. 16 ›› Issue (7): 411-415.

• 中药药物警戒与合理用药专栏 • 上一篇    下一篇

《本草纲目》儿科有毒中药用毒与防毒思想研究

王笑1,2, 石琳1,2, 张冰1,2,*   

  1. 1 北京中医药大学,北京 100029;
    2 北京中医药大学中药药物警戒与合理用药研究中心,北京 100029
  • 收稿日期:2019-08-06 修回日期:2019-08-06 出版日期:2019-07-20 发布日期:2019-08-06
  • 通讯作者: 张冰,女,教授,主任医师·博导,中药药物警戒与合理用药研究、中药药性理论基础与应用。E-mail：zhangbing6@263.net
  • 作者简介:王笑,女,在读硕士,中药药物警戒与合理用药研究。
  • 基金资助:
    国家自然科学基金（81874349）：辛热类有毒中药风险-效益阈与效毒机制研究

Study on Use and Prevention of Pediatric Drug Toxicity in the Compendium of Materia Medica

WANG Xiao1,2, SHI Lin1,2, ZHANG Bing1,2,*   

  1. 1 Beijing University of Traditional Chinese Medicine, Beijing 100029, China;
    2 Center for Pharmacovigilance and Rational Use of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
  • Received:2019-08-06 Revised:2019-08-06 Online:2019-07-20 Published:2019-08-06

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摘要： 目的 总结分析《本草纲目》中应用有毒中药治疗小儿疾病的用毒防毒思想,为儿科有毒中药的应用提供参考借鉴。方法 应用Excel 2016版提取梳理《本草纲目》儿科毒性药物项下[气味]、[附方]等项,建立儿科有毒中药数据库,通过频次统计等方法分析其适应证、炮制、配伍、使用方法等情况,研究其用毒防毒思想。结果 应用于儿科的有毒中药共71种,毒性多为有毒和小毒,附方共136首,内服的药物多炮制后入方,用量以一字、半钱居多,使用时多配以米饮或醋调,并且注重配伍减毒。结论 《本草纲目》儿科有毒中药的记载蕴含丰富的药物警戒思想,用毒防毒思想突出,对现代儿科合理用药具有一定指导意义。

关键词: 本草纲目, 儿科, 有毒中药, 用毒防毒

Abstract: Objective To provide some reference for pediatric drug toxicity based on thoughts of use and prevention of pediatric drug toxicity from the Compendium of Materia Medica. Methods To extract factors such as smell and prescriptions of pediatric drug toxicity from the Compendium of Materia Medica, to establish a database of pediatric application of traditional Chinese medicine(TCM) toxicity with Excel 2016. With the database then its indications, processing, compatibility and application were statistically analyzed. Results There are 71 different kinds of TCM toxicity were used in pediatrics. Most of the drug toxicities are with mediocre or little poison. The majority of the prescriptions, 136 in total, are oral drugs which were processed first and then put into the prescriptions. The dosages were mostly measured with "Yi Zi" and "Ban Qian", and they were often used with vinegar or liquids which were made of rice. During the process, the compatibility of reducing toxicity should be focused. Conclusion The pediatric drug toxicity in the Compendium of Materia Medica contains rich clinical practice of pharmacovigilance, especially on its thoughts of use and prevention drug toxicity, which should be a good guidance for rational drug use in modern pediatrics.

Key words: Compendium of Materia Medica, pediatrics, toxic TCM, use and prevention of drug toxicity

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