中国药物警戒 ›› 2021, Vol. 18 ›› Issue (10): 975-977.
DOI: 10.19803/j.1672-8629.2021.10.17

• 安全与合理用药 • 上一篇    下一篇

某三甲医院儿科门诊超说明书用药情况调查及影响因素分析

宋士卒1, 王婉菁2   

  1. 1安徽医科大学第一附属医院药剂科,国家中医药管理局中药化学三级实验室,安徽 合肥 230022;
    2上海用正医药科技有限公司,四川 成都 610041
  • 收稿日期:2020-02-02 出版日期:2021-10-15 发布日期:2021-10-27
  • 作者简介:宋士卒,男,本科,副主任药师,药学。

Influencing Factors of Off-label Use of Drugs among Pediatric Outpatients at a Tertiary Hospital

SONG Shizu1, WANG Wanjing2   

  1. 1Department of Pharmacy, The First Affiliated Hospital of Anhui Medical University, The Grade 3 Pharmaceutical Chemistry Laboratory of State Administration of Traditional Chinese Medicine, Hefei Anhui 230022, China;
    2Shanghai Yongzheng Medical Science and Technology Co., Ltd.,Chengdu Sichuan 610041, China
  • Received:2020-02-02 Online:2021-10-15 Published:2021-10-27

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摘要： 目的 通过对某三甲医院儿科门诊3个月超说明书用药情况进行回顾性调查,讨论其影响因素,促进儿科门诊安全用药。方法 采用单纯随机抽样方法从该院2018年10月1日至2018年12月31日的门诊处方中抽取儿科处方共19 686张,根据判断标准对超说明书用药情况进行评判统计。结果 超说明书用药处方共5 445张,超说明书用药发生率为27.7%。主要的超说明书用药类型为超给药剂量（41.9%）,超年龄给药（30.2%）以及超给药频次（20.1%）。各类别药物超说明书用药发生率较多的为呼吸系统用药（54.0%）和抗感染药（25.6%）。超说明书用药发生率构成比最多的年龄段为学龄前期（35.7%）、其次为幼儿期（28.2%）和学龄期（18.9%）。结论 该院儿科门诊超说明书用药情况发生率较高,需要制定相关措施,限制不必要的超说明书用药,保障患者安全。

关键词: 儿科门诊, 超说明书用药, 发生率

Abstract: Objective To retrospectively investigate the off-label use of drugs in a pediatric outpatient clinic of a hospital within three months, to study results and influencing factors, and to promote the safe use of drugs in pediatric outpatient clinics. Methods A total of 19 686 pediatric prescriptions were chosen from the outpatient prescriptions of the hospital between October 1, 2018 and December 31, 2018 using the simple random sampling method. According to related criteria, the off-label use of drugs was calculated and analyzed. Results A total of 5 445 prescriptions involving off-label use of drugs were found. The incidence of off-label use of drugs was 27.7%. The off-label use of drugs largely involved overdosing (41.9%), overage patients (30.2%) and medication at too short intervals (20.1%). Drugs for the respiratory system (54.0%) and anti-infectives (25.6%) were used in most of the cases of off-label use of drugs. The age group with the highest proportion of off-label use of drugs was pre-school children (35.7%), followed by infants (28.2%) and school-age children (18.9%). Conclusion The incidence of off-label use of drugs in this pediatric outpatient clinic is high. It is necessary to formulate relevant measures to minimize off-label use of drugs and ensure patients' safety.

Key words: a pediatric clinic, off-label use of drugs, incidence

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