中国药物警戒 ›› 2019, Vol. 16 ›› Issue (6): 374-378.

• 安全性评价与合理用药 • 上一篇    下一篇

1189例卡前列甲酯栓药品不良反应报告分析

张纾1, 林强1,*, 邓文2, 陈深3   

  1. 1福建省药品不良反应监测中心,福建 福州 350002;
    2福州市医疗保障基金管理中心,福建 福州 350005;
    3福州市药品不良反应监测中心,福建 福州 350014
  • 收稿日期:2019-07-12 修回日期:2019-07-12 出版日期:2019-06-20 发布日期:2019-07-12
  • 通讯作者: 林强,女,硕士,主任药师,药品不良反应监测与评价。E-mail:908121385@qq.com
  • 作者简介:张纾,女,硕士,主管药师,药品不良反应监测与评价。

Analysis of 1189 Cases of Adverse Drug Relations Induced by Carboprost Methylate

ZHANG Shu1, LIN Qiang1,*, DENG Wen2, CHEN Shen3   

  1. 1 Center for ADR Monitoring of Fujian, Fujian Fuzhou 350002, China;
    2 Fuzhou Medical Security Fund Management Center, Fujian Fuzhou 350005, China;
    3 Center for ADR Monitoring of Fuzhou, Fujian Fuzhou 350014, China
  • Received:2019-07-12 Revised:2019-07-12 Online:2019-06-20 Published:2019-07-12

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摘要： 目的 探讨卡前列甲酯栓不同给药途径下的药品不良反应发生规律及特点,为临床合理用药提供依据。方法 对2005~2017年泛珠三角不良反应网络管理平台收集的卡前列甲酯栓药品不良反应/事件报告从患者性别、年龄、既往史、用药原因、给药途径、不良反应发生时间、不良反应表现和不良反应累及系统-器官等进行回顾性分析。结果 卡前列甲酯栓药品不良反应多在用药当天发生,药品不良反应累及胃肠系统损害、全身性损害和皮肤及附件损害等,严重不良反应多在用药后半小时出现。结论 临床应重视该药的不良反应,特别是严重不良反应,药品生产企业应及时修订完善药品说明书,保障患者用药安全。

关键词: 卡前列甲酯栓, 药品不良反应, 合理用药

Abstract: Objective To investigate the general characteristics and relative factor of the adverse drug reactions induced by carboprost methylate, so as to provide reference of clinical rational and safe use of drug. Methods By retrospective study method, we analyzed the 1 189 cases of adverse drug relations/events induced by carboprost methylate in the adverse reaction network platform of Pan-Pearl River Delta from 2005 to 2017. By retrospective study method, we analyzed the patient's age, gender, past history, the purpose of drug use,occurrence time, symptoms of adverse drug reactions, the system involved etc. Results The adverse drug reactions of carboprost methylate mainly occurred on the day of medication. The systems involved of adverse drug reactions include the gastrointestinal system damage, systemic damage,skin and its accessories damage etc.Serious adverse drug reactions mostly occurred in half an hour after the drug use. Conclusion Clinic should pay attention to the drug adverse reactions of carboprost methylate, especially to the serious adverse reactions.Drug manufacturers should promptly revise and improve the safety information of drug instructions,so as to ensure the safety of drug use.

Key words: carboprost methylate, adverse drug reaction, rational use of drug

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