中国药物警戒 ›› 2017, Vol. 14 ›› Issue (4): 249-253.

• 安全性评价与合理用药 • 上一篇    下一篇

医院集中监测法在呼吸内科住院患者药品不良反应监测中的应用

林志强, 王大璇, 章宝燕   

  1. 福建医科大学附属泉州第一医院药剂科,福建 泉州 362000
  • 收稿日期:2017-07-05 修回日期:2017-07-05 出版日期:2017-04-20 发布日期:2017-07-05
  • 作者简介:林志强,男,副主任药师,临床药学与药品不良反应监测。
  • 基金资助:
    泉州市科技计划项目（2016Z032）：

Application of Intensive Hospital Monitoring in Adverse Drug Reaction Supervision of Inpatients Admitted to Respiratory Department

LIN Zhi-qiang, WANG Da-xuan, ZHANG Bao-yan   

  1. Department of Pharmacy, the Affiliated Quanzhou First Hospital of Fujian Medical University, Fujian Quanzhou 362000, China
  • Received:2017-07-05 Revised:2017-07-05 Online:2017-04-20 Published:2017-07-05

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摘要： 目的 探讨医院集中监测法在呼吸内科住院患者药品不良反应（ADR）监测中的作用。方法 以我院呼吸内科2个诊疗组2016年1至6月收治的全部患者为观察对象,2名临床药师每日分别参加这2个诊疗组的查房工作,根据医院集中监测法的要求,详细记录每例患者的基本信息、原发疾病、用药情况以及ADR发生情况,分析比较不同年龄组患者ADR发生率和应用不同种类药物患者的ADR发生情况。结果 纳入监测的患者共1 003 例,其中138 例出现ADR,ADR发生率为13.76 %。 >80岁组患者ADR发生率（31.43 %,11/35）明显高于其他各年龄组（均P<0.05)。出现不良反应的药品共计27种,居前3位的药品种类分别为抗菌药物（8种）、抗肿瘤药（6种）和抗结核药（4种）,共占66.67 %。结论 在呼吸内科应用医院集中监测法可以揭示不同病种、不同年龄段以及不同药品ADR的发生率和临床表现,从而进行针对性的药学监护,保障患者用药安全。

关键词: 医院集中监测, 呼吸内科, 药品不良反应

Abstract: Objective To investigate the role of intensive hospital monitoring in the adverse drug reactions (ADR) supervising among inpatients in respiratory department. Methods All in-hospital patients admitted to the two treatment groups of respiratory department from January to June in 2016 were selected as observation subjects. Two clinical pharmacists were dispatched to the two treatment groups to participate in the daily ward-rounds. Each patient’s basic information, primary disease, drug use and ADR occurrence were recorded detailedly, and the incidence of ADR among different age groups as well as ADR occurrence in those patients who use different kinds of drugs were analyzed and compared, according to the requirements of the intensive hospital monitoring method. Results A total of 1, 003 patients were enrolled in the study, of which 138 cases presented ADR, with an incidence of ADR 13.76%. The incidence of ADR (31.43 %, 11/35) in group over 80-year-old was significantly higher than that in other age groups (average P < 0.05). Twenty-seven drugs were associated with ADRs, and the top three categories were antibacterial drugs (8 species), anti-tumor drugs (6 species) and anti-tuberculosis drugs (4 species), accounting for 66.67 % of all ADRs. Conclusion By applying intensive hospital monitoring method in respiratory department, the incidence and clinical manifestations of ADR have been revealed in different diseases, different ages and different drug use. Thus, patients can receive targeted pharmaceutical care, so as to ensure the safety of medication.

Key words: intensive hospital monitoring, department of respiratory, adverse drug reaction（ADR)

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