中国药物警戒 ›› 2017, Vol. 14 ›› Issue (12): 764-768.

• 安全性评价与合理用药 • 上一篇    

院内外延伸药学服务对2型糖尿病患者治疗效果及不良反应发生率的影响

潘凤珍1,张平2,张金梅3*   

  1. 1 常州市金坛人民医院 江苏 常州 213200；
    2徐州市沛县人民医院 江苏 徐州 221600；
    3上海交通大学附属胸科医院，上海 200030
  • 收稿日期:2017-10-23 修回日期:2018-01-19 出版日期:2017-12-20 发布日期:2018-01-19
  • 通讯作者: 张金梅，女，本科，副主任护师，临床护理。E-mail:13918136467@163.com
  • 作者简介: 潘凤珍，女，本科，副主任药师，医院药学。

Effects of Extended Pharmaceutical Care in and out of Hospital on Therapeutic Effect and Adverse Reactions in Patients with Type 2 Diabetes Mellitus

PAN Feng-zhen1 ,ZHANG Ping2 , ZHANG Jin-mei3*   

  1. 1Changzhou Jintan Dstrict People's Hospital, Jiangsu Changzhou 213200, China;
    2Xuzhou Peixian People's Hospital, Jiangsu Xuzhou 221600, China;
    3Thoracic Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200030, China
  • Received:2017-10-23 Revised:2018-01-19 Online:2017-12-20 Published:2018-01-19

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摘要： 目的 探讨院内外延伸药学服务对2型糖尿病患者血糖控制效果、用药依从性及不良反应的影响。方法 选取2016年1月-2017年1月本院收治的142例2型糖尿病患者为研究对象，随机分为研究组和对照组，每组各71例。对照组患者进行常规药学服务；研究组患者在常规医疗服务的基础上进行用药教育、电话随访等院内外药学延伸服务。比较两组患者干预前后糖化血红蛋、空腹血糖水平、血糖水平达标率、用药依从性以及不良反应发生率的差异。结果 干预前，两组患者糖化血红蛋白、空腹血糖水平及血糖达标率、用药依从性比较，均无统计学差异（P >0.05）。干预后，两组患者糖化血红蛋白及空腹血糖水平均显著降低，血糖达标率均显著升高，且研究组均明显优于对照组，年龄<60岁患者血糖控制效果优于年龄≥60岁患者，均具有统计学差异（P <0.05）。干预后，两组用药依从性良好率均显著提高，且研究组显著高于对照组，年龄<60岁患者用药依从性改善程度优于年龄≥60岁患者，均具有统计学差异（P <0.05）。干预后，研究组患者不良反应发生率显著低于对照组，具有统计学差异（P <0.05）。结论 院内外延伸药学服务有助于2型糖尿病患者血糖水平的控制，并可提高药物依从性，降低不良反应发生率，尤其对年龄<60岁患者的效果更好。

关键词: 2型糖尿病, 延伸药学服务, 血糖控制, 用药依从性, 不良反应

Abstract: Objective To explore the effects of extended pharmaceutical care in and out of hospital on blood glucose control, medication compliance and adverse reactions in patients with 2 type diabetes mellitus. Methods 142 patients with type 2 DM in our hospital from January 2016 to January 2017 were enrolled and randomly divided into study group and control group, 30 cases in each group. The control group received routine pharmaceutical care; the study group additionally received extended pharmaceutical care in and out of hospital as medication education, telephone follow-up, etc. The levels of glycosylated hemoglobin, fasting blood glucose, rate of blood glucose compliance, medication compliance and rate of adverse reactions were compared between the two groups of patients before and after intervention. Results There was no statistical difference in the levels of glycosylated hemoglobin, fasting blood glucose, rate of blood glucose compliance and medication compliance between the two groups before intervention (P >0.05). After intervention, the levels of glycosylated hemoglobin and fasting blood glucose of patients in the two groups were significantly decreased (P<0.05); the rate of blood glucose compliance was significantly increased (P <0.05); those in the study group were significantly better than the control group (P <0.05); the blood glucose control effect in patients ＜ 60 years old were significantly better than patients ≥ 60 years old (P <0.05). After intervention, the rate of good medication compliance was significantly increased in the two groups (P <0.05); that in the study group was significantly better than the control group (P <0.05); the improvement of medication compliance in patients ＜ 60 years old was significantly better than patients ≥ 60 years old (P <0.05). After intervention, the rate of adverse reactions in the study group was significantly lower than the control group (P <0.05). Conclusion The extended pharmaceutical care in and out of hospital could contribute to blood glucose control, improve the medication compliance, decrease the rate of adverse reactions, especially for patients ＜ 60 years old.

Key words: 2 type diabetes mellitus, extended pharmaceutical care, blood glucose control, medication compliance, adverse reaction

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