中国药物警戒 ›› 2016, Vol. 13 ›› Issue (3): 173-175.

• 安全性评价与合理用药 • 上一篇    下一篇

我院129例乳腺癌患者紫杉醇注射液化疗的不良反应分析

刘岩松1,赵昆2,张国强3   

  1. 1山东大学附属肿瘤医院,山东 济南 250000;
    2莱芜市妇幼保健医院,山东 莱芜271100;
    3广饶县妇幼保健医院,山东 东营257300
  • 收稿日期:2016-02-01 修回日期:2016-04-12 出版日期:2016-03-20 发布日期:2016-04-12
  • 作者简介:刘岩松,男,本科,副主任医师,乳腺癌的诊断及治疗。

Analysis of 129 Cases of Adverse Drug Reactions Induced by Paclitaxel Injection in Patients with Breast Cancer in Our Hospital

LIU Yan-song1， ZHAO Kun2， ZHANG Guo-qiang3   

  1. 1Affiliated Tumor Hospital of Shandong University, Shandong Jinan 250000, China;
    2Maternal and Child Healthcare Hospital of Laiwu City, Shandong Laiwu 271100, China;
    3Maternal and Child Health Care Hospital of Guangrao County, Shandong Dongying 257300, China
  • Received:2016-02-01 Revised:2016-04-12 Online:2016-03-20 Published:2016-04-12

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摘要： 目的 研究紫杉醇注射液临床不良反应的特点。方法 筛选我院129例使用紫杉醇注射液进行治疗产生不良反应的乳腺癌患者,提取患者的年龄、给药方案、ADR发生时间、临床表现等进行整理、归纳和分析。结果 129例患者产生的不良反应累及器官主要为神经及精神系统损害,皮肤及其附件损害,肝脏损害,心血管系统损害以及全身性损害,不良反应以脱发、手足麻木、转氨酶升高最为常见。采取相应措施后,这些患者基本都恢复正常。结论 紫杉醇注射液引起的不良反应较多,且特征明显。临床上应该随时注意患者的症状,给予及时有效的治疗,降低紫杉醇在抗癌治疗中的不良反应,更好地发挥其疗效。

关键词: 乳腺癌, 紫衫醇, 不良反应, 分析

Abstract: Objective To research the characteristics of adverse drug reactions (ADRs) induced by paclitaxel injection. Methods 129 cases of ADRs induced by paclitaxel injection in our hospital were chosen. The information of patients’ age, drug administration program, time of occurrence, clinical manifestation of ADR were extracted and analyzed. Results In the 129 cases of ADRs, neurological and psychiatric system damage, skin and its appendages damage, liver damage, cardiovascular system damage and systemic injury were mainly involved. Alopecia, deadlimb and transaminase elevation were the most common ADRs. After taking the corresponding measures, these patients basically returned to normal. Conclusion The adverse reactions caused by paclitaxel injection were common and the characteristics were obvious. We should always pay attention to the patients ’ symptoms, give timely and effective treatment, so as to decrease the adverse reactions while exerting better efficacy.

Key words: breast cancer, paclitaxel, adverse reaction, analysis

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