中国药物警戒 ›› 2016, Vol. 13 ›› Issue (3): 169-172.

• 安全性评价与合理用药 • 上一篇    下一篇

178例脉络宁注射液不良反应的文献分析

孙丽,唐汉武   

  1. 广州中医药大学第三附属医院,广东 广州 510000
  • 收稿日期:2015-12-14 修回日期:2016-04-12 出版日期:2016-03-20 发布日期:2016-04-12
  • 作者简介:孙丽,女,硕士,主管中药师,中药临床药学。

Literature Analysis of 178 Cases of Adverse Drug Reactions Induced by Mailuoning Injection

SUN Li ,TANG Han-wu   

  1. Third Affiliated Hospital of Guangzhou TCM University, Guangdong Guangzhou 510000, China
  • Received:2015-12-14 Revised:2016-04-12 Online:2016-03-20 Published:2016-04-12

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摘要： 目的 探讨脉络宁注射液所致不良反应（ADR）的一般规律及特点,为临床合理用药提供参考。方法 检索1992~2015年国内公开发表的有关脉络宁注射液致不良反应的个案报道,并将收集到的178例ADR信息进行统计分析。结果 脉络宁注射液所致的ADR与性别无关,多发生于41~65岁的中年患者;用药30 min内发生ADR占62.92%,以全身性损害及呼吸系统损害为主;临床表现主要为呼吸困难、过敏性休克;有2例患者死亡,其余患者经对症治疗后均恢复正常。结论 脉络宁注射液可致严重ADR及说明书中未描述的ADR,应加强用药监测,发生ADR时及时处理,以确保患者用药安全。

关键词: 脉络宁注射液, 药品不良反应, 文献分析

Abstract: Abstract:Objective To analyze general regularity and characteristics of Mailuoning injection-induced ADRs,and provide references for clinical rational drug use. Methods Literatures about Mailuoning injection-induced ADRs published between 1992 and 2015 were retrieved,and 178 ADR cases reports were analyzed statistically. Results Mailuoning injection-induced ADRs had no association with gender,and often occurred in patients between 41~65 years old, 62.92% cases occurred within 30 mins after medication ,and the ADR cases mainly manifested as systemic damage and respiratory system damage. The main clinical manifestations were dyspnea and allergic shock. There were 2 death cases,and other patients recovered after symptomatic treatment. Conclusion Mailuoning injection can induce serious adverse reactions,and some kinds of ADRs were undescribed in instructions,so we should strengthen the medication monitoring and treating ADR timely to ensure the safety of patient medication.

Key words: Mailuoning injection, adverse drug reaction (ADR), literature analysis

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