中国药物警戒 ›› 2014, Vol. 11 ›› Issue (12): 729-731.

• 兰索拉唑与中药联合治疗专栏 • 上一篇    下一篇

兰索拉唑临床应用和不良反应研究进展

李明华1, 冯群2, 3, 李晓宇2, 李三鸣4, 孙蓉2 *   

  1. 1山东罗欣药业集团股份有限公司,山东 临沂 276017;
    2山东省中医药研究院,山东 济南 250014;
    3天津中医药大学,天津 300193;
    4沈阳药科大学,辽宁 沈阳 110016
  • 收稿日期:2014-10-27 修回日期:2016-02-03 出版日期:2014-12-08 发布日期:2016-03-02
  • 通讯作者: 孙蓉,博士,研究员·博导,中药药理与毒理。
  • 作者简介:李明华,学士,研究员,药学。
  • 基金资助:
    国家重大新药创制科技重大专项课题：中药复方药理学研究及药效学评价关键技术（2009ZX09502-015）,注射用兰索拉唑技术升级及增加临床适应症的研究（2014ZX09201-003-001）

Research Progress of Clinical Applications and Adverse Reactions of Lansoprazole

LI Ming-hua1, FENG Qun2, 3, LI Xiao-yu2, LI San-ming4, SUN Rong2, *   

  1. 1Shandong Luoxin Pharmacy Stock Co., Ltd., Shandong Linyi 276017, China; 2Shandong Academy of Chinese Medicine, Shandong Jinan 250014, China; 3Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; 4Shenyang Pharmaceutical University, Liaoning Shenyang 110016, China
  • Received:2014-10-27 Revised:2016-02-03 Online:2014-12-08 Published:2016-03-02

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摘要： 目的明确兰索拉唑临床应用和不良反应,为药物的应用范围及其安全性问题提供文献依据和研究思路。方法对近十几年来兰索拉唑国内外相关临床药理作用和不良反应报道进行整理、归纳与分析。结果兰索拉唑常用于十二指肠溃疡、胃溃疡、反流性食管炎、卓-艾综合征等各种消化功能紊乱性疾病,其疗效高,不良反应少。结论建议在临床应用兰索拉唑时,应严格按照药品说明书和相关指南,对症用药,控制用药剂量与疗程,减少药品不良反应发生,注重联合用药尤其是中西药物联合用药的指征、用法、用量、疗程的研究,提高用药合理性和有效性。

关键词: 兰索拉唑, 质子泵抑制剂, 消化功能紊乱性疾病, 不良反应

Abstract: ObjectiveTo explore the clinical applications and adverse reactions of lansoprazole and provide literature basis and idea for the application range and safety issues of lansoprazole. MethodsReferences in the last decades at home and abroad about the clinical pharmacological actions and adverse reactions of lansoprazole were collated, analyzed and summarized. ResultsLansoprazole is always used to treat the diseases of duodenal ulcer, gastric ulcer, reflux esophagitis, Zollinger-Ellison syndrome and other digestive function disorder diseases. Compared with other proton-pump inhibitors, lansoprazole has the advantages of higher curative effect and less adverse reactions. ConclusionWe'd better be in accordance with the drug instructions or under the guidance of pharmacist when lansoprazole has to be used for the corresponding disease. The dosages and treatment course should be controlled to reduce adverse reactions. At the same time, the researches of indication, usage, dosage and treatment course of lansoprazole combined with Chinese herbs and/or western medicine should be paid more attention to improve its rationality and effectiveness.

Key words: lansoprazole, proton-pump inhibitor, digestive function disorder disease, adverse reaction

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