中国药物警戒 ›› 2013, Vol. 10 ›› Issue (7): 421-423.

• 药械安全性研究 • 上一篇    下一篇

35例口腔内用药的不良反应分析

任丽洁1,于平1,徐作国2   

  1. 1.烟台市口腔医院,山东烟台264000；
    2.烟台市心理康复医院山东莱阳265200
  • 收稿日期:2013-01-10 修回日期:2016-03-09 出版日期:2013-07-08 发布日期:2016-03-09
  • 通讯作者: 徐作国,男,副主任医师,精神科临床和药品不良反应监测。E-mail：xuzuoguo@126.com
  • 作者简介:任丽洁,女,本科,主管药师,药品不良反应监测。

Analysis of 35 Cases of Adverse Drug Reaction Induced by Intra-oral Medication

REN Li-jie1 ,YU Ping1, XU Zuo-guo2   

  1. 1.Yantai Stomatological Hospital, Shandong Yantai 264000, China;2Psychorehabilitation Hospital of Yantai, Shandong Laiyang 265200, China
  • Received:2013-01-10 Revised:2016-03-09 Online:2013-07-08 Published:2016-03-09

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摘要： 目的 探讨口腔科口腔内用药的不良反应发生原因与规律,为临床安全用药提供参考。方法 对我院2009 年6月1 日～2012 年10 月30 日期间住院和门诊患者的口腔内局部用药不良反应病例进行统计分析。结果 35 例口腔内用药不良反应涉及5 种药品；阿替卡因肾上腺素注射液占75%；单项用药占88.57%；85.71%的不良反应发生在用药后3 天内；不良反应主要有18 种临床表现。结论 口腔内用药有局限性,用药剂量小,不良反应相对较轻,虽然安全性较高,但应注意预防感染。

关键词: 药品不良反应, 监测, 口腔内用药

Abstract: Objective To discuss the adverse drug reaction (ADR) induced by dentistry intra-oral medication, and to provide the reference for clinical medication safety. Methods ADR reports of inpatient and outpatient at our hospital were statistically analyzed since June 2009 to October 2012. Results 35 cases of intra-oral medication adverse reaction were involved in5 kinds of medicines. Articaine hydrochloride and epinephrine tartrate injection accounted for 75%. Single medication accounted for 88.75%. 85.71% adverse reactions happened in3 days. There were 18 kinds of clinical manifestations. Conclusion Intra -oral medication has limitations, small doses, and adverse reaction happened less. Despite the higher security, attention to should be paid prevent infection.

Key words: adverse drug reaction, monitor, intra-oral medication

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