中国药物警戒 ›› 2013, Vol. 10 ›› Issue (7): 424-426.

• 药械安全性研究 • 上一篇    下一篇

格列本脲致低血糖反应的文献分析

郭美华1,邱晓红2,马满玲1*,胡宝荣1,马妍妍1,刘世萍1   

  1. 1.哈尔滨医科大学附属第一医院药学部,黑龙江哈尔滨150001；
    2.哈尔滨市公安医院药剂科,黑龙江哈尔滨150027
  • 收稿日期:2013-01-01 修回日期:2016-03-09 出版日期:2013-07-08 发布日期:2016-03-09
  • 通讯作者: 马满玲,女,硕士,主任药师,临床药学及药理。 E-mail：mamanling@126.com
  • 作者简介:郭美华,女,硕士,主管药师,临床药学及药品质量控制。
  • 基金资助:
    “胰岛素药物流行病学的研究”,紫禁城国际药师论坛科研课题项目,编号：CJP-1101-25。

Literature Analysis of the Low Blood Sugar Reactions Caused By Glibenclamide

GUO Mei-hua1 QIU Xiao-hong2 MA Manling1* HU Bao-rong1 MA Yan-yan1 LIU Shi-ping1   

  1. 1.Department of Pharmacy, the First Affiliated Hospital of Harbin Medical University, Heilongjiang Harbin 150001, China;
    2.Harbin Public Security Hospital, Heilongjiang Harbin 150027, China
  • Received:2013-01-01 Revised:2016-03-09 Online:2013-07-08 Published:2016-03-09

PDF (PC)

265

摘要： 目的 探讨格列本脲致低血糖反应发生的情况并分析相关因素,为临床合理用药提供参考。方法对格列本脲致的742 例低血糖反应文献进行分类统计与分析。结果男女比例为1.1:1,老年人占88.0%,39.6%的病例存在不合理用药行为,14.6%单独用药,43.9%联合用药,临床表现以低血糖昏迷为主（62.7%）,93.5%病例治愈,48 例转归不良（死亡41 例）。结论格列本脲可引起较为严重的低血糖反应,甚至可致死亡,使用时须慎重考虑年龄、用法用量等相关因素,做到合理用药,减少低血糖反应的发生。

关键词: 格列本脲, 药源性低血糖, 合理用药

Abstract: Objective To analyze the cases of low blood sugar reactions caused by glibenclamide and identify the relevant factors, provide a reference for the clinical use of drugs. Methods 742 cases of glibenclamide -induced low blood sugar reactions were statistically analyzed. Results Male to Female ratio was 1.1:1,88.0% of the cases are the elderly, 39.6% of them had non -standard situation of drug use, 14.6% of them used single drug, 43.9% of them had the combined use of drugs. Clinical types of the cases were mainly hypoglycemic coma(62.7% ), 93.5% of them were cured ,48 cases showed adverse outcome (death in 41 cases). Conclusion Glibenclamide can cause relatively severe low blood sugar reactions, and even lead to death. When use, the age, usage, dosage and other factors must be carefully considered, so as to medicate rationally and then reduce the incidence of hypoglycemia.

Key words: glibenclamide, drug-induced hypoglycemia, rational drug use

中图分类号: