中国药物警戒 ›› 2025, Vol. 22 ›› Issue (2): 211-216.
DOI: 10.19803/j.1672-8629.20240456

• 安全与合理用药 • 上一篇    下一篇

某市精神卫生中心安神类中成药用药分析

周坤1,2, 马良1,2,*, 李肇丰1,2, 曹斌1,2, 顾洪伟1,2, 刘茜1,2   

  1. 1武汉市精神卫生中心药学部,湖北 武汉 430012;
    2武汉市心理医院药学部,湖北 武汉 430012
  • 收稿日期:2024-07-02 出版日期:2025-02-17 发布日期:2025-02-17
  • 通讯作者: *马良,男,博士,副主任药师,临床药物治疗与药事管理。E-mail:ma6025343@163.com
  • 作者简介:周坤,男,硕士,主管药师,临床药物治疗与药事管理。
  • 基金资助:
    国家自然科学基金资助项目（81901302）; 武汉市医学科研项目（WZ20Q02）

Usage of Nerve-Calming Chinese Herbal Patent Medicines in a Mental Health Center

ZHOU Kun1,2, MA Liang1,2,*, LI Zhaofeng1,2, CAO Bing1,2, GU Hongwei1,2, LIU Qian1,2   

  1. 1Department of Pharmacy, Wuhan Mental Health Center, Wuhan Hubei 430012, China;
    2Department of Pharmacy, Wuhan Hospital for Psychotherapy, Wuhan Hubei 430012, China
  • Received:2024-07-02 Online:2025-02-17 Published:2025-02-17

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摘要： 目的 调查某市精神卫生中心安神类中成药应用情况,为安神类中成药合理和规范使用提供参考。方法 采用逸耀合理用药软件对中心医院信息系统(Hospital Information System, HIS) 2018至2023年安神类中成药门诊处方进行审核,统计各品种用药天数、计算用药频度(Defined Daily Dose, DDDs)、限定日费用（Defined Daily Cost, DDC）和药物利用指数(Drug Utilization Index, DUI)以评估用药合理性。结果 2018~2023年DDDs排名前5位分别为甜梦口服液、疏肝解郁胶囊、解郁丸、健脑胶囊和舒眠胶囊;各品种安神中成药DUI介于0.30~0.99;123 989张中成药处方中筛查出6 657张不合理处方,不合理率5.37%,其中不合理类型以无适应证用药（13.70%）、用法用量不适宜（12.36%）和遴选药品不适宜（2.60%）为主。结论 2018至2023年安神类中成药使用量平稳增长,使用整体合理、规范,不合理用药发生率低,但仍应警惕甜梦口服液、解郁丸、巴戟天寡糖胶囊等可能发生不合理用药情况。

关键词: 安神类中成药, 用药频度, 限定日费, 药物利用指数, 用药分析, 合理用药, 精神卫生中心

Abstract: Objective To investigate the usage of Chinese herbal patent medicines for calming nerves in a mental health center and to provide references for rational use of related drugs. Methods The YI-Yao Rational Drug Use Software System was used to review the prescriptions for nerve-calming Chinese herbal patent medicines from the Hospital Information System (HIS). The rationality of drug use was evaluated in terms of the days of drug use, defined daily dose (DDDs), defined daily cost (DDC) and drug utilization index (DUI). Results The top five drugs in terms of DDDs between 2018 and 2023 were Tian-meng oral liquid, Shu-gan-Jie-yu capsules, Jie-yu pills, Jian-nao capsules and Shu-mian capsules, and DUI ranged from 0.30 to 0.99. A total of 6657 improper prescriptions were screened out of 123 989 prescriptions for Chinese herbal patent medicines, so the rate of substandard prescriptions was 5.37% involving prescriptions for wrong indications (13.70%), inappropriate usage and dosage (12.36%), and inappropriate selection of drugs (2.60%). Conclusion From 2018 to 2023, the total usage and varieties of Chinese herbal patent medicines increased stably. Despite the low incidence rate of irrational use of these drugs, clinicians need to use some varieties with caution.

Key words: Chinese Herbal Patent Medicine for Calming Nerves, Defined Daily Dose (DDDs), Defined Daily Cost (DDC), Drug Utilization Index (DUI), Medication Analysis, Rational Drug Use, Mental Health Center

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