关键词: 药物性肝损害, 不良反应, 合理用药

Abstract: Objective To analyze clinical features and causative agents of drug-induced liver injury and provide reference for clinical use accordingly. Methods Ninety -four cases of drug -induced liver injury from clinical reports in our hospital from Jan 2010 to Dec 2012 were collected and analyzed retrospectively. Results The average age was 49.82±16.32 years old(from 2 to 86y) in the 94 patients including male 56 and female 36 cases. In their previous histories, there were drug allergies in 24 cases(25.53%) and liver diseases in 8 cases(8.51%). Fifty-five kinds of drugs were involved in the 94 drug-induced liver injury cases in which lipid-lowering drugs ranked first(31.92%), antibiotics ranked second (20.21%) and antipyretic analgesics and nervous system drugs ranked third(9.57%). The clinical types of drug-induced liver injury in these cases included liver cell type in 61 cases(64.89%), cholestasis type in 19 cases(21.27%) and mixed type in 14 cases(14.89%). More common in varying degrees of clinical manifestations were fatigue, anorexia, nausea, vomiting and other gastrointestinal reactions. The latent period was1～4 weeks. Conclusion The types of drug-induced liver injury drugs are diversed. During the course of medication, regularly checking liver function and discontinuing medication are the main measures to reduce drug-induced liver injury.

Key words: drug-induced liver injury, adverse reaction, rational drug use