中国药物警戒 ›› 2013, Vol. 10 ›› Issue (3): 172-174.

• 药械安全性研究 • 上一篇    下一篇

242例胰岛素致过敏反应文献分析

马满玲,郭美华,杨丽杰,胡宝荣,王金华   

  1. 哈尔滨医科大学附属第一医院药学部,黑龙江哈尔滨 150001
  • 收稿日期:2012-06-01 修回日期:2016-03-09 出版日期:2013-03-08 发布日期:2016-03-09
  • 作者简介:马满玲,女,主任药师,临床药学及药理。
  • 基金资助:
    紫禁城国际药师论坛科研课题项目：胰岛素药物流行病学的研究。编号：CJP1101-25

Literature Analysis of 242 Cases of Allergic Reactions Caused by Insulin

MA Man-ling, GUO Mei-hua, YANG Li-jie, HU Bao-rong, WANG Jin-hua   

  1. Department of Pharmacy, the First Affiliated Hospital of Harbin Medical University, Heilongjiang Harbin 150001, China
  • Received:2012-06-01 Revised:2016-03-09 Online:2013-03-08 Published:2016-03-09

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摘要： 目的 了解胰岛素致过敏反应发生的情况并分析相关因素,为临床合理用药提供参考。方法 对胰岛素所致的242 例过敏反应文献进行分类统计与分析。结果 男女比例为1.1:1,61.1%的病例为老年人,15.7%的病例既往有过敏反应史,91.3%的患者皮下注射给药,50.0%的病例使用预混胰岛素,80.2%病例发生在多次用药后,过敏反应以局部反应为主（57.0%）,绝大多数的病例被治愈或好转。结论 胰岛素可引起较为严重的过敏反应,甚至可致休克,使用时须慎重考虑年龄、用法用量等相关因素,做到合理用药,减少过敏反应的发生。

关键词: 胰岛素, 过敏反应, 合理用药

Abstract: Objective To understand the cases of allergic response caused by insulin, analyze the relevant factors, and providea reference for the clinical use of drugs. Methods 242 cases of insulin-induced allergic reactions were statistically analyzed. Results Male to Female ratio was 1.1:1, 61.1% of the cases involved the elderly, 15.7% of the patients had allergy history, 91.3% of the allergies were due to subcutaneous injection, 50.0% of the patients administered premixed insulin, 80.2% of the cases occurred aftera few or many times administration. The main allergic reactions were local reactions(57.0%), and could be cured or improved mostly. Conclusion Insulin may cause serious allergic reactions and even shock. When we use this drug, we must carefully consider the age, usage, dosage and other relevant factors, then make rational use of drugs to reduce the incidence of allergic reactions.

Key words: insulin, allergic reactions, rational drug use

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