中国药物警戒 ›› 2013, Vol. 10 ›› Issue (2): 96-100.

• 药械安全性研究 • 上一篇    下一篇

190例他汀类降脂药品不良反应病例分析

曾婷婷   

  1. 成都市药品不良反应监测中心,四川成都 610042
  • 收稿日期:2012-09-06 修回日期:2016-03-09 出版日期:2013-02-08 发布日期:2016-03-09
  • 作者简介:曾婷婷,女,硕士,助理研究员,药品不良反应监测。

Analysis of 190 Reports of Adverse Drug Reaction Induced by Statins

ZENG Ting-ting   

  1. Chengdu Adverse Drug Reaction Monitoring Center, Sichuan Chengdu 610042, China
  • Received:2012-09-06 Revised:2016-03-09 Online:2013-02-08 Published:2016-03-09

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摘要： 目的 探讨他汀类降脂药品导致不良反应发生的可能原因和影响因素,为血脂异常人群长期安全用药提供建议。方法对四川省自2004 年1 月至2012 年6 月期间,通过国家药品不良反应监测系统网络上报的190 例他汀类降脂药品致不良反应病例报告进行统计分析。结果他汀类降脂药品的不良反应以皮疹、肌损害、胃肠道反应、肝功能损害为主；部份不良反应累及神经系统和血液系统；严重不良反应以肝损害最常见。结论应规范降脂用药的剂量和时限,避免超时与超剂量用药,加强院外患者的用药后复诊和随访,减少不良反应的发生。

关键词: 他汀类, 降脂药物, 药品不良反应, 统计分析

Abstract: Objective To investigate the characteristics and influence factors of adverse drug reactions (ADR) induced by statins. Methods 190 reports of adverse drug reactions induced by statins, collected from Sichuan ADR Monitoring Center via National ADR Monitoring System from Jan. 2004 to Jun. 2012 were analyzed. Results Skin le sions, muscle lesions, gastrointestinal system and liver function failure were the most common adverse reaction of statins, some nervous system and blood system abnormals followed. The serious adverse reactions frequently involved liver dysfunction. Conclusion Lipid -lowering drugs should be strictly regulated by dose and time -limit, to avoid any overtime or overdose medication. To emphasize the return consultation and follow-ups of out-patients may reduce the incidence of adverse reaction in statins.

Key words: statins, lipid-lowering drugs, adverse drug reaction, statistical analysis

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