中国药物警戒 ›› 2013, Vol. 10 ›› Issue (2): 114-116.

• 药械安全性研究 • 上一篇    下一篇

人用狂犬病疫苗不良反应文献分析

蔡伟1,冯巧巧2,廉亚玲3,董铎4   

  1. 1.青海省药品不良反应监测中心,青海西宁 810007；
    2.山东省药品不良反应监测中心,山东济南 250013；
    3.甘肃省张掖市食品药品监督管理局,甘肃张掖 734000；
    4.国家食品药品监督管理局药品评价中心,北京 100045
  • 收稿日期:2012-03-01 修回日期:2016-03-09 出版日期:2013-02-08 发布日期:2016-03-09
  • 通讯作者: 董铎,女,硕士,副主任药师,药品不良反应监测。E-mail:dongduo@cdr.gov.cn
  • 作者简介:蔡伟,男,主治医师,药品不良反应监测与评价。

Analysis of Domestic Literature on Adverse Reactions Induced by Rabies Vaccine

CAI Wei1 ,FENG Qiao-qiao2 ,LIAN Ya-ling3 ,DONG Duo4   

  1. 1.Qinghai Center for ADR Monitoring, Qinghai Xining 810007, China;
    2.Shandong Center for ADR Monitoring,Shandong Jinan 250013, China;
    3.Zhangye Food and Drug Administration, Gansu Zhangye 734000,China;
    4.Center For Drug Reevaluation, SFDA, Beijing 100045, China
  • Received:2012-03-01 Revised:2016-03-09 Online:2013-02-08 Published:2016-03-09

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摘要： 目的 分析人用狂犬病疫苗不良反应的特点,以供临床参考。方法 采用文献回顾性研究方法,对1979～2008年《中国知识资源总库》报道的 72例人用狂犬病疫苗不良反应进行综合性分析。结果 患者男女比例无明显差异,15岁以下患者比例高于其他年龄段；累及系统 -器官以皮肤及其附件损害最为常见；严重不良反应为过敏性休克。结论 应加强人用狂犬病疫苗不良反应监测,提高临床安全用药意识,确保患者用药安全、有效。

关键词: 人用狂犬病疫苗, 不良反应, 文献分析

Abstract: Objective The characteristics of adverse reactions induced by rabies vaccine were analyzed to provide reference for the clinical use. Methods 72 adverse reaction cases induced by rabies vaccine were analyzed retrospectively. Results There is no significant difference between the proportion of female and male patients. The proportion of patients under 15 years old is higher than that of other age groups. The skin and accessories damage is the most common. The serious adverse reaction is anaphylactic shock. Conclusion In order to ensure the safe and effective medication in the clinic, the adverse reaction monitoring of rabies vaccine and the awareness of drug safety should be strengthened.

Key words: rabies vaccine, adverse reaction, literature analysis

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