中国药物警戒 ›› 2013, Vol. 10 ›› Issue (2): 103-106.

• 药械安全性研究 • 上一篇    下一篇

174例苯乙双胍致乳酸性酸中毒文献分析

张新建,郭美华*,杨丽杰,刘世萍,胡宝荣   

  1. 哈尔滨医科大学附属第一医院,黑龙江哈尔滨 150001
  • 收稿日期:2012-05-07 修回日期:2016-03-09 出版日期:2013-02-08 发布日期:2016-03-09
  • 通讯作者: 郭美华,女,硕士,主管药师,临床药学及药品质量控制。 E-mail：justgoguo@126.com
  • 作者简介:张新建,男,副主任药师,医院药学。

Literature Analysis of 174 Cases of Lactic Acidosis Caused by Phenformin

ZHANG Xin-jian, GUO Mei-hua*, YANG Li-jie,LIU Shi-ping ,HU Bao-rong   

  1. The First Affiliated Hospital of Harbin Medical University, Heilongjiang Harbin 150001, China
  • Received:2012-05-07 Revised:2016-03-09 Online:2013-02-08 Published:2016-03-09

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摘要： 目的 调查苯乙双胍所致乳酸性酸中毒反应发生的情况并分析相关因素,为临床合理用药提供参考。方法 对苯乙双胍所致的174 例乳酸性酸中毒文献进行分类统计与分析。结果 男女比例为1.4:1,≥60 岁病例占已知年龄病例的76.8%,合并用药的构成占较高比例,75.3%的病例每日用量超过75mg,70.3%的病例用药时间超过半年,92.0%的病例存在诱发因素,63.2%病例治愈或好转,死亡64 例（36.8%）。结论 苯乙双胍可致乳酸性酸中毒反应,严重者可致脏器衰竭,甚至可致死亡,使用时须慎重考虑年龄、用法用量、用药时间等相关因素,做到合理用药,减少不良反应的发生。

关键词: 苯乙双胍, 药品不良反应, 乳酸性酸中毒, 用药安全性, 合理用药

Abstract: Objective To provide a rational pharmacotherapy of phenformin by investigating the lactic acidosis induced by phenformin. Methods 174 lactic acidosis cases of phenformin were statistically analyzed. Results Male female ratio was 1.4:1, 76.8% of the patients were over 60 years old. For 75.3% of the cases, the dosage of the drug daily was more than 75 mg. For 70.3% of the patients, drug use time was more than halfa year, 92.0% of cases had the induced factors, 63.2% of the patients were cured or improved, 64patients died(36.8%). Conclusion Phenformin can cause lactic acidosis, severe cases can lead to organ failure, and even death. When using this drug should consider carefully the age, usage and dosage, course of treatment and other related factors, ensure rational drug use so as to reduce the incidence of adverse drug reactions.

Key words: phenformin, adverse drug reaction, lactic acidosis, safty of medication, rational administration

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