中国药物警戒 ›› 2013, Vol. 10 ›› Issue (12): 749-751.

• 药械安全性研究 • 上一篇    下一篇

钆喷酸葡胺注射液不良反应的文献分析

王宇,陈伟,杨班君*   

  1. 中国医学科学院肿瘤医院药剂科,北京 100021
  • 收稿日期:2013-04-26 修回日期:2016-03-09 出版日期:2013-12-08 发布日期:2016-03-09
  • 通讯作者: 杨珏君,女,硕士,副主任药师,临床药学。 E-mail:yangjun_99@126.com
  • 作者简介:王宇,女,本科,主管药师,临床药学。

Literature Analysis on the Adverse Drug Reactions of Gd-DTPA

WANG Yu, CHEN Wei ,YANG Jun*   

  1. Deportment of Pharmacy, Cancer Hospital of Chinese Academy of Medical Sciences, Beijing 100021, China
  • Received:2013-04-26 Revised:2016-03-09 Online:2013-12-08 Published:2016-03-09

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摘要： 目的 分析钆喷酸葡胺注射液发生不良反应特点及相关因素,为临床合理用药提供参考。方法 对万方数据库 2002～2012年发表的文献进行检索,对涉及钆喷酸葡胺注射液不良反应病例的信息进行分类统计分析。结果 发生不良反应的男女比例为 1:1.2,多数不良反应发生在用药后 30min内。非过敏反应有59例（44%）；轻度过敏性反应有47例（35%）；中度过敏性反应10例（8%）；重度过敏性反应18例（13%）,其中死亡有6例（4%）。结论 虽然钆喷酸葡胺注射液不良反应发生率较低,但仍可引起严重的过敏反应,甚至休克死亡,由于其使用多在缺少临床医护监护的影像诊断科,所以更应加强其监测。

关键词: 钆喷酸葡胺注射液, 药品不良反应, 文献分析

Abstract: Objective To explore the situation and rules of adverse drug reactions of Gd -DTPA injection, in order to provide reference for the rational use of drugs in clinic. Methods We collected the literatures related to the adverse reactions of Gd -DTPA injection in WANFANG Database from 2002 to 2012, and conducteda statistical analysis. Results The Results showed that the ratio of male to female was 1:1.2. Most adverse reactions occurred whthin 30 minutes after medication. There were 59 cases(44%) of non-allergic reactions, 47 cases(35%) of mild allergic reactions, 10 cases(8 % ) of moderate allergic reactions ,18 cases( 13% ) of severe allergic reactions ,of which 6 cases ( 4% ) died. Conclusion In spite of Gd-DTPA injection with low incidence of adverse reaction, it can still cause severe allergic reactions and even death. Pharmacists should strengthen the monitoring because of its use in imaging diagnosis without clinical care.

Key words: Gd-DTPA injection, adverse drug reaction, literature analysis

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