药源性耳聋防治研究进展

中国药物警戒 ›› 2013, Vol. 10 ›› Issue (12): 730-733.

药源性耳聋防治研究进展

司继刚

山东省淄博市中心医院药学部,山东淄博 255036

收稿日期:2013-06-04 修回日期:2016-03-09 出版日期:2013-12-08 发布日期:2016-03-09
作者简介:司继刚,男,硕士,副主任药师,医院药事管理与临床药学。

Advances in Prevention and Treatment of Drug-induced Deafness

SI Ji-gang

Department of Pharmacy, Central Hospital of Zibo, Shandong Zibo 255036, China

Received:2013-06-04 Revised:2016-03-09 Online:2013-12-08 Published:2016-03-09

摘要/Abstract

摘要： 为进一步了解耳毒性药物的种类和致聋机理,探讨预防和治疗耳聋的策略,对国内外近些年来报道的药源性耳聋相关文献进行整理、总结,药物的耳毒性与遗传、用药剂量、用药时间、给药途径、患者年龄和身体状况等有关。耳毒性药物涉及品种众多,造成的后果严重,应引起临床重视,加强临床合理用药,以预防为主,早发现,早治疗,减轻患者痛苦。

关键词: 药源性耳聋, 耳毒性, 氨基糖苷类, 合理用药

Abstract: In order to further understand the types of ototoxic drugs and the mechanism of deafness, and to explore the prevention and treatment strategies of drug -induced deafness, literatures about drug -induced deafness at home and abroad in recent years were collected, summarized and analyzed. The ototoxicity of drugs is related not only with hereditary, dose, length of time and administration route, but also with age and physical condition. The ototoxic drugs involve many kinds of chemicals and they will cause unimaginably serious consequence. More attention should be paid in clinical practice,clinical rational drug use should be strengthened. Prevention first and appropriate treatment as early as possible are the therapeutic strategies of the drug-induced deafness.

Key words: drug-induced deafness, ototoxicity, aminoglycosides, rational drug use

中图分类号:

R969.3

司继刚. 药源性耳聋防治研究进展[J]. 中国药物警戒, 2013, 10(12): 730-733.

SI Ji-gang . Advances in Prevention and Treatment of Drug-induced Deafness [J]. Chinese Journal of Pharmacovigilance, 2013, 10(12): 730-733.

参考文献

[1] 刘新,黄德亮,袁永一,等. 药物性耳聋及防治策略[J].中国药物应用与监测, 2008, 5(2):31-34.
[2] 邱素梅.569 例聋儿病因及早期干预的分析[J].中国中西医结合耳鼻喉科杂志, 2010, 18(5):268-269.
[3] Li Z,Li R,Chen J,et a1.Mutational analysis Of the mitochondrial 12SrRNAgene in Chinese pediatric subjects with aminoglycosideinduced and non-syndromic hearing loss[J].Hum Genet,2005,117（1）：9-15.
[4] 刘晓雯,郭玉芬,关静,等.中国西北地区801 例聋哑学生临床流行病学病因分析[J].听力学及言语疾病杂志,2008, 16(2): 99-102.
[5] Karasawa T, Wang Q, David L L. Calreticulin binds to gentamicin and reduces drug-induced ototoxicity[J].Toxicol Sci, 2011, 124(2):378-387.
[6] Shen M R,Chou C Y,Chiu W T.Streptomycin and its analogues are potent inhibitors of the hypotonicity-induced Ca2+entry and Cl channel active ity[J].FEBS Lett,2003,554(3)：494-500.
[7] Takamoto K,Kawada M,Usui T,et a1.Aminoglycoside antibiotics reduce glucose reabsorption in kidney through down-regulation of SGLTl[J].BiochemBiophys Res Commun,2003,308(4)：866-871.
[8] Kawamoto K,Sha S H,Minoda R,et a1.Antioxidant gene therapy can protect hearing and hair cells from ototoxicity[J].Mol Ther,2004,9(2)：173-181.
[9] Roland P S.New developments in our understanding of ototoxicty[J].Ear Nose Throat J,2004,83(9 Suppl 4)：15-17.
[10] 施炳超.静滴阿奇霉素致双侧耳闭1 例[J].海峡药学,2010,22（9）：229-230.
[11] 杨新华,李时琪.静脉滴注阿奇霉素引起严重耳鸣1 例[J].安徽医药,2010,14(4)：488.
[12] 吴春雷,黄银平,张军. 静滴阿奇霉素致耳鸣[J].健康必读杂志,2011,4(4),329-330.
[13] 范志刚,王仙平,张红云. 红霉素肠溶片致耳毒性1 例[J].中国药师, 2012,15(2): 256.
[14] 李道佩,陈冬梅.浅谈药物的耳毒性[J].中国药物与临床,2006,6(6)：441.

[1]	范凯凯, 王聪, 刘洪峰, 王西勇. 临床药师对某院丙氨酰谷氨酰胺注射液应用干预分析[J]. 中国药物警戒, 2024, 21(2): 181-184.
[2]	李应芬, 韩雷. 319例注射用脑蛋白水解物药品不良反应报告分析[J]. 中国药物警戒, 2024, 21(2): 195-198.
[3]	黎杏仁, 沈爱宗, 苏丹. 质子泵抑制剂预防胆胰外科围术期应激性黏膜病变的合理性评价[J]. 中国药物警戒, 2023, 20(9): 1022-1026.
[4]	史香芬, 孙志勇, 张旭锋, 卢晓静, 杜书章, 张晓坚. 基于智能信息管理系统的门诊麻精药品全流程管理[J]. 中国药物警戒, 2023, 20(8): 899-903.
[5]	霍艳飞, 田月洁, 许莉莉, 谢彦军, 常虹, 孙春晓, 李霞. 535例氢溴酸高乌甲素制剂新的和严重的药品不良反应报告分析[J]. 中国药物警戒, 2023, 20(8): 921-926.
[6]	刘婧, 夏亮, 张世杰. 1例多元药物过敏急性胰腺炎患者行药物激发试验的药学监护[J]. 中国药物警戒, 2023, 20(7): 822-824.
[7]	范秀丛, 董晓慧, 陈丹霞, 鲍思蔚, 马雅斌. 1例妊娠期艰难梭菌感染伴尿路感染患者的药学监护[J]. 中国药物警戒, 2023, 20(5): 579-582.
[8]	殷进军, 王淑伟, 邵姜超, 王冰. 基于加权TOPSIS法的贝伐珠单抗注射液药物利用评价[J]. 中国药物警戒, 2023, 20(12): 1421-1426.
[9]	刘斌, 邵美玲, 蔡怡然, 马丰懿, 兰鸿. 戴明环循环管理在提高门诊处方合理率中的应用价值[J]. 中国药物警戒, 2022, 19(9): 1035-1039.
[10]	庄红艳, 臧彦楠, 刘珊珊, 牛梦溪, 房萌, 尹冬青, 果伟. 唑吡坦致神经精神系统不良反应分析[J]. 中国药物警戒, 2022, 19(8): 889-892.
[11]	马冰冰, 张晓朦, 张冰, 林志健, 吕锦涛. 基于文献分析的老年人中成药合理用药与药学服务思考[J]. 中国药物警戒, 2022, 19(6): 595-599.
[12]	李晓菲, 程蓉, 吴雪梅, 刘智. 注射用特利加压素的安全性分析[J]. 中国药物警戒, 2022, 19(6): 654-656.
[13]	陈方方, 张红旭. 大剂量甲氨蝶呤治疗原发性中枢神经系统淋巴瘤的药学实践[J]. 中国药物警戒, 2022, 19(4): 446-449.
[14]	靳浩槟, 郑磊, 杨静, 管玉瑶, 张晓丽. 住院患者皮肤药品不良反应及伴随的肝肾功能异常分析[J]. 中国药物警戒, 2022, 19(3): 310-312.
[15]	徐喆, 鞠萍, 罗琪, 杨欢, 汪洋. 930例儿童抗菌药物不良反应分析[J]. 中国药物警戒, 2022, 19(3): 317-321.