中国药物警戒 ›› 2013, Vol. 10 ›› Issue (11): 670-672.

• 药械安全性研究 • 上一篇    下一篇

我院2011年胺碘酮注射液不良反应监测报告分析

谭晓燕,李一石*,刘玉清,娄莹,张晓星   

  1. 中国医学科学院阜外心血管病医院,北京 100037
  • 收稿日期:2013-03-28 修回日期:2016-03-09 出版日期:2013-11-08 发布日期:2016-03-09
  • 通讯作者: 李一石,女,主任医师,博士生导师,心内科。 E-mail：Liyishi@public3.bta.net.cn
  • 作者简介:谭晓燕,女,博士,副主任医师,心内科。

Analysis of Monitoring Reports of Adverse Reactions Induced by Amiodarone Injection at Our Hospital in 2011

TAN Xiao-yan ,LI Yi-shi* ,LIU Yu-qing, LOU Ying ,ZHANG Xiao-xing   

  1. Fuwai Hospital, Beijing 100037, China
  • Received:2013-03-28 Revised:2016-03-09 Online:2013-11-08 Published:2016-03-09

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摘要： 目的 对我院2011 年1 月至2012 年3 月胺碘酮注射液不良反应进行分析,以期为临床安全合理用药提供参考。方法 对我院2011年1月至2012年3月胺碘酮注射液（n=396）的使用情况及病历资料进行回顾性研究,对其导致的肝功能异常、需干预的低血压和缓慢性心律失常及尖端扭转型室速等不良反应进行统计与分析。结果 胺碘酮注射液致肝功能异常的发生率为14.6%,第一个24h静脉胺碘酮总量越大肝功能越易受损伤。需干预的低血压8 例,需干预的严重心动过缓4例,尖端扭转室速2例。结论 在密切监测下,胺碘酮注射液不良反应发生率低,应用安全有效。

关键词: 胺碘酮注射液, 不良反应, 肝功能异常

Abstract: Objective To summarize and analyze the adverse reactions(ADR) induced by amiodarone injection from Jan. 2011 to Mar. 2012 at our hospital, and to guide the rational drug use. Methods A retrospective study was conducted on the use and medical records of amiodarone injection(n=396) from Jan. 2011 to Mar. 2012 at our hospital, the adverse reactions of abnormal hepatic function , hypotension and bradycardia needing intervention , Torsade de Pointes which were caused by amiodarone injection were counted and analyzed. Results The incidence of the abnormal hepatic function induced by amiodarone injection was 14.6%, the more total quantity of intravenous amiodarone in 24 hours, the more hepatotoxicity the patients got. There were8 patients with hypotension and 4 with severe bradycardia needing intervention, and there were 2 patients with Torsade de Pointes. Conclusion The incidence of adverse reactions of amiodarone injection is low and it's safe under intensive monitoring.

Key words: amiodarone injection, adverse reactions, abnormal hepatic function

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