中国药物警戒 ›› 2013, Vol. 10 ›› Issue (11): 673-675.

• 药械安全性研究 • 上一篇    下一篇

磷霉素治疗细菌性痢疾的疗效及不良反应的文献分析

范燕   

  1. 国家食品药品监督管理局药品评价中心,北京 100045
  • 收稿日期:2013-11-08 修回日期:2016-03-09 出版日期:2013-11-08 发布日期:2016-03-09
  • 作者简介:范燕,女,硕士,药理学及药品不良反应监测与评价。

Literature Analysis of Curative Effect and Adverse Drug Reaction of Bacillary Dysentery Treated by Fosfomycin

FAN Yan   

  1. Center for Drug Reevaluation, SFDA, Beijing 100045, China
  • Received:2013-11-08 Revised:2016-03-09 Online:2013-11-08 Published:2016-03-09

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摘要： 目的 通过对磷霉素治疗细菌性痢疾的文献报道进行分析,评价磷霉素对细菌性痢疾的疗效及不良反应,以期为临床安全合理用药提供参考。方法 以“磷霉素”并含“细菌性痢疾”为主要检索词,检索CNKI 数据库1980～2012 年间涉及磷霉素治疗细菌性痢疾的文献报道,分别从治愈、有效、无效3 个疗效标准及不良反应的发生情况等方面进行统计分析。结果共检索出32 篇2 911 例病例,治愈2 708 例（93.03%）,有效179 例（6.15%）；无效24 例（0.82%）；发生不良反应63 例（2.16%）。结论 采用磷霉素治疗细菌性痢疾疗效明显,不良反应症状轻且发生率低,在临床治疗细菌性痢疾方面值得选用。

关键词: 磷霉素, 细菌性痢疾, 疗效, 药品不良反应, 文献分析

Abstract: Objective To analyze the curative effect and adverse drug reaction of bacillary dysentery treated by fosfomycin. Methods Actual data related to bacillary dysentery treated by fosfomycin spanning years 1980～2012 were collected from the China National Knowledge Infrastructure(CNKI). Datas should be analyzed through cure,effective, invalid and adverse drug reaction. Results Actual data originated from 32 publications encompassing 2911 cases including 2708 cases of cure, 179 cases of effective, 24 cases of invalid and 63 cases of adverse drug reaction. Conclusion There were obvious curative effect and low incidence rate of adverse drug reaction in bacillary dysentery treated by fosfomycin.

Key words: fosfomycin, bacillary dysentery, curative effect, adverse drug reaction, literature analysis

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