114例质子泵抑制剂不良反应病例分析

中国药物警戒 ›› 2013, Vol. 10 ›› Issue (1): 39-41.

114例质子泵抑制剂不良反应病例分析

梁茂本,孟祥梅

南京医科大学附属淮安第一医院,江苏淮安 223300

收稿日期:2012-06-13 修回日期:2016-03-12 出版日期:2013-01-08 发布日期:2016-03-09
作者简介:梁茂本,男,本科,副主任药师,医院药学。

Analysis of 114 Cases of ADR Induced by PPI

LIANG Mao –ben, MENG Xiang –mei

Huai'an First People's Hospital, Nanjing Medical University, Jiangsu Huai'an 223300, China

Received:2012-06-13 Revised:2016-03-12 Online:2013-01-08 Published:2016-03-09

摘要/Abstract

摘要： 目的探讨质子泵抑制剂（PPI）不良反应(ADR)的特点及相关因素,为临床合理用药提供参考。方法利用“维普医药信息镜像系统”、“万方数据医药信息镜像系统”、“中国医院数字图书馆”,对2001 年1 月~2011 年12 月国内公开报道的PPI 所致的114ADR 例进行统计分析。结果114 例ADR 患者中男性72 例（63.16%）,女性42 例（36.84%）,奥美拉唑最高79 例（69.30%）,临床主要表现为精神神经系统、消化系统、心血管系统等。结论临床应高度重视PPI的ADR,以确保安全用药。

关键词: 关健词：质子泵抑制剂, 不良反应, 文献

Abstract: Objective To explore the features and contributing factors of adverse drug reaction(ADR) induced by proton pump inhibitors (PPIs) and provide rational use of drugs in clinic. Methods A statistical analysis was conducted on 114 cases of ADR publicly reported during the year from January 2001 to December 2011 via the use of VIP Medical Information System(VMIS), Wanfang Medical Information System, and Chinese Hospital Digital Database. Results Of all the 114 cases, male patients amount to 72, accounting for 63.16%; Female 42 cases, comprising 36.84%. The ADR induced by Omeprazole reach up to 79 cases, making up 69.30%, and clinic ADR is mainly observed on the nervous system, the digestive system and the cardiovascular system. Conclusion High importance should be attached to the ADR induced by PPIs in clinic to ensure the safe use of drugs.

Key words: PPI, ADR, literature

中图分类号:

梁茂本,孟祥梅. 114例质子泵抑制剂不良反应病例分析[J]. 中国药物警戒, 2013, 10(1): 39-41.

LIANG Mao –ben, MENG Xiang –mei. Analysis of 114 Cases of ADR Induced by PPI [J]. Chinese Journal of Pharmacovigilance, 2013, 10(1): 39-41.

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