中国药物警戒 ›› 2013, Vol. 10 ›› Issue (1): 16-18.

• 参莪汤抗肿瘤作用研究 • 上一篇    下一篇

参莪汤相关物质基础抗肿瘤作用研究进展

孙蓉1,谢元璋12   

  1. 1.山东省中医药研究院,山东济南250014；
    2.哈尔滨商业大学生命科学与环境科学研究中心,黑龙江哈尔滨150076
  • 收稿日期:2011-05-14 修回日期:2016-03-12 出版日期:2013-01-08 发布日期:2016-03-09
  • 作者简介:孙蓉,女,博士,研究员,博士生导师,中药药理与毒理。
  • 基金资助:
    国家重大新药创制专项课题：中药复方药理学研究与药效评价关键技术（2009ZX09502-015）；山东省重大新药创制综合性大平台中药单元技术平台中药药理子平台建设（2009ZX09301-013）

Research Progress on Material Basis of Chinese Herbal Compound Shenetang for Anti-tumor Effect

SUN Rong1 ,XIE Yuan-zhang1,2   

  1. 1.Shandong Research Academy of TCM, Shandong Jinan 250014, China;
    2.Center of Research and Development on Life Sciences and Environmental Sciences, Harbin University of Commerce, Heilongjiang Harbin 150076, China
  • Received:2011-05-14 Revised:2016-03-12 Online:2013-01-08 Published:2016-03-09

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摘要： 目的 探索参莪汤相关物质基础抗肿瘤作用研究现状,明确参莪汤抗肿瘤作用机制,为进一步实验研究参莪汤的抗肿瘤作用提供文献依据和研究思路。方法 对近15年有关于参莪汤相关物质基础抗肿瘤作用文献进行归纳、分析和总结。结果 参莪汤的抗癌物质基础主要通过诱导肿瘤细胞凋亡、抑制肿瘤血管生成、端粒及端粒酶的稳定性、抑制癌基因的表达、促进抑癌基因的表达等多个环节抑制肿瘤的发生、发展与转移,而且方中许多中药可以同时作用于上述多个环节。结论 目前从天然药物中寻找新的抗肿瘤药已经成为世界医药界的研究热点,细胞和分子水平的研究指标在实验中的广泛应用,为中药治疗胃癌提供了更可靠的依据。

关键词: 参莪汤, 抗肿瘤, 机制

Abstract: Objective The research of the material basis of Chinese herbal compound shen'e soup for anti -tumor effect was reviewed, in order to explore the antitumor mechanism, to provide literature basis and research ideas for further study of anti -tumor effect. Methods The literatures on material basis of Chinese herbal compound shen'e soup for anti-tumor effect were summarized and analyzed in the past twenty years. Results Its anticancer treatment of material basis from shen'e soupl mainly perish through the induction of tumor cell, suppress the production of tumor blood vessel, stability of the end grain and the end grain of enzyme, suppress the expression of cancer gene, to promote the expression of damping the cancer gene and so on. There are many links to suppress the occurrence, development and the shift of the tumor, moreover in the formula many traditional Chinese medicines may simultaneously affect many links above. Conclusion At present it had already become the world's research hot spot to sought for the new an ti -tumor medicine from the natural medicine, that the cell and molecular level research target widespread applica tion in the experiment, provide a more reliable basis in treating the gastric cancer for the traditional Chinese medicine.

Key words: Shenetang, anti-tumor, mechanism

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